BRISTOL MYERS SQUIBB

Two immunotherapy drugs, Opdivo and Yervoy, significantly improve long-term survival in advanced melanoma patients, with a median survival of six years compared to six to nine months before immunotherapy. The combination treatment reduced the risk of death by 47% and showed 52% survival at 10 years, excluding non-melanoma deaths.

Bristol Myers Squibb presents 10-year CheckMate -067 data showing durable survival benefit with Opdivo plus Yervoy in advanced melanoma, with 43% of patients alive at 10 years, compared to 25% a decade ago. Data published in The New England Journal of Medicine.

About half of metastatic melanoma patients treated with immune checkpoint inhibitors survive cancer-free for 10+ years, per a 10-year follow-up study from Weill Cornell Medicine and Dana-Farber Cancer Institute. The CheckMate 067 trial, involving 945 patients, showed nivolumab and ipilimumab combination significantly improved outcomes, with no new safety concerns. Median survival increased from 6.5 months to over 6 years, and patients free from cancer progression at 3 years likely remain disease-free at 10 years.

The United States RNA Polymerase Inhibitor Market is projected to reach USD xx.x billion by 2031, driven by advancements in clinical diagnostics and precision medicine. Key players include Johnson & Johnson, AstraZeneca, and Pfizer. Market segments include types like Veliparib and applications in hospital, retail, and online pharmacies. Regional analysis highlights North America's dominance, Europe's strategic alliances, and Asia-Pacific's growing energy demand.

The SUNNIFORECAST trial found that the dual checkpoint inhibitor regimen ipilimumab/nivolumab significantly improved overall survival at 12 months compared to standard of care (SOC) in patients with non-clear cell renal cell cancer (nccRCC), with a median overall survival of 42.4 months versus 33.9 months for SOC.

Morgan Stanley's Terence Flynn maintains a Sell rating on BMY stock due to potential FDA labeling concerns for KarXT, despite high anticipation for its schizophrenia treatment approval. Flynn anticipates a 5% stock decrease if KarXT's label includes restrictive measures, and significant growth hinges on KarXT's Alzheimer's disease psychosis indication or ABBV's emraclidine failure. Barclays also assigns a Sell rating with a $42.00 price target.

iTeos Therapeutics' mid-stage trial results show its drug, when combined with GSK's immunotherapy, shrank lung tumors in twice as many patients compared to GSK's therapy alone. The trial raised safety concerns due to three treatment-related deaths from immune-related inflammation. Despite previous failures of TIGIT-targeting drugs, iTeos' data could rekindle interest in the target, with further data expected to clarify the combination's impact on survival and disease progression.

BMS's BMS-986012 nearly doubled overall survival in ES-SCLC patients with brain metastases in a Phase II trial, with an OS of 16.3 months vs. 8.7 months in the control group. The study compares BMS-986012, Opdivo, and chemotherapy versus Opdivo plus chemotherapy.

R.A.S., M.S.T., C.Y., R.N., H.S.R., M.D., A.J.C., E.S.-R., J.C.B., C.O., K.K., A.D.E., C.V., N.W., K.S.A., A.S.C., C.F., C.I., A.T., J.T., K.Y., L.H., K.G., F.M.H., T.S., A.L.A., P.B., P.N., G.L.H., W.F.S., J.P., P.P., A.D.M., D.Y., L.J.v.V., N.M.H., L.J.E. report various institutional research funding, advisory roles, consultancy, honoraria, patents, and stock ownership.