Rapamycin Counteracts Valproate's Harmful Effects on Fetal Spinal Cord Development
• Researchers found that Sodium Valproate, an epilepsy drug, can cause spinal malformations in fetuses during pregnancy.
• Using human mini-spinal cords (organoids), they discovered that Valproate changes the cells that form the spinal cord, leading to malformations.
• Co-treatment with Rapamycin prevented the negative effects of Valproate on the organoids, potentially allowing safer use of the epilepsy drug during pregnancy.
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