Pheast partnered with Lonza for PHST001 manufacturing, enabling clinical trial supply. PHST001 targets CD24, a 'don’t eat me' signal in cancers. Pheast’s origins trace to Amira Barkal’s research at Stanford, leading to CD24’s therapeutic development. CD24 differs from CD47, offering a more potent effect. Pheast’s discovery process involved diverse models, resulting in a suitable clone. The company looks to CD47 programs for scaling guidance but acknowledges dosing uncertainties. Protein engineering efforts yielded a well-expressed antibody, positioning Pheast for clinical demands.