The UAE, through the Emirati Genome Programme and Abu Dhabi Biobank, is pioneering disease prevention and precision medicine. M42’s Omics Centre of Excellence, the region’s largest, supports these efforts with genetic sequencing and AI analysis, aiming to transform healthcare in the UAE and set a global standard. Initiatives include genomic screening, polygenic risk scores, pre-marital screening, newborn screening, liquid biopsy in cancer, and pharmacogenomics. The centre also houses the Abu Dhabi Biobank, featuring the region’s largest hybrid cord blood bank, enhancing stem cell transplant success. Public awareness and trust in genomics remain key challenges.