WORLD HEALTH ORGANIZATION

The anti-aging drugs market is projected to grow from $53.76 billion in 2023 to $77.85 billion in 2028, driven by aging populations, product innovations like SkinCeuticals' A.G.E Interrupter Advanced, and emerging technologies such as senolytic drugs and gene therapy.

39 million people live with HIV, 630,000 died in 2022, and 1.3 million acquired the disease. UNAIDS aims to end HIV/AIDS by 2030. Challenges include HIV's ability to integrate into host genomes, forming latent reservoirs, and global disparities in treatment access. Innovative strategies like Dr. Ho's nanomedicine targeting CCR5 and Nef aim to prevent and treat HIV. Dr. Mann's HIV-like particles (HLP) reactivate dormant HIV for cART and immune system targeting, moving towards clinical trials for a potential cure.

Advanced technology reshapes healthcare through precision, efficiency, and accessibility, enhancing diagnostics, treatment, and patient monitoring. Innovations like telemedicine, smart devices, AI, IoMT, and wearable health devices improve accuracy, patient care, and accessibility. However, challenges such as data security, privacy issues, and high development costs must be addressed. Future trends like personalized medicine and AI-robotics integration promise to redefine medical practices.

Obesity affects 2.5 billion adults globally, with 890 million classified as obese. The market for obesity drugs could grow 15-fold by 2030. India's obesity rate is 6.5%, affecting 100 million people. Challenges include weight stigma and bias, with 82% reporting reduced physical functioning. Emerging trends include sedentary lifestyles and poor dietary choices. Obesity treatment has evolved with new medications and personalized approaches. Lilly plans to launch tirzepatide in India by 2025.

Malaria control strategies, including indoor residual spraying (IRS) and insecticide-treated nets (ITNs), have influenced mosquito behavior and resistance. Studies highlight increased outdoor feeding and reduced indoor feeding among Anopheles gambiae populations post-intervention. Pyrethroid resistance in African anopheline mosquitoes poses challenges. Attractive toxic sugar bait (ATSB) methods show promise in vector control. Integrated vector management is crucial for malaria control, with ongoing research focusing on optimizing these strategies.

References discuss various treatments and classifications for lymphoid neoplasms, cutaneous lymphomas, and mycosis fungoides/Sezary syndrome, including extracorporeal photopheresis, dimethyl fumarate, and mogamulizumab, highlighting their mechanisms and clinical applications.

Rimas V. Lukas, MD, discusses STELLAR trial (NCT02796261) efficacy data on eflornithine plus lomustine vs lomustine in recurrent IDH-mutant anaplastic astrocytoma per 2021 WHO criteria.

AmiLyfe Bioscience's innovative amino acid hydration technology aims to improve global health by enhancing water absorption, with potential applications in treating dehydration, malnutrition, and gut health issues, particularly in vulnerable populations.

Insud Pharma secures $2.7M from Gates Foundation for Phase II trial of thermostable sublingual oxytocin to prevent postpartum hemorrhage, aiming to reduce maternal mortality in low-resource regions.

Eflornithine + lomustine combo showed clinically meaningful OS & PFS improvements in grade 3 IDH mutant astrocytoma patients, per Orbus Therapeutics' Phase 3 STELLAR study.