DRC, facing a severe mpox outbreak, received 99,100 vaccine doses from the EU, aiming for nearly 200,000 total. Over 19,000 cases and 650 deaths highlight the urgency. Vaccine logistics are challenging due to DRC's size and infrastructure. The WHO declared mpox an international emergency, prompting global health organizations to contribute. The EMA approved Bavarian Nordic's mpox vaccine for adolescents, emphasizing vulnerable populations. Comprehensive public health measures, including education and community engagement, are crucial alongside vaccination efforts.