WORLD HEALTH ORGANIZATION

MARIPOSA study shows RYBREVANT® plus LAZCLUZE™ provides superior outcomes vs osimertinib in first-line EGFR-mutant NSCLC, with improved overall survival and CNS disease control.

Make America Healthy Again PAC, founded by ex-RFK Jr. campaign staff, urges supporters to vote Trump to bring RFK Jr.'s policies to forefront. PAC aims to align RFK Jr.'s policies with Trump's leadership, focusing on health, agriculture, and corruption. Kennedy may join Trump's administration if elected.

The WHO's mpox declaration led to significant stock market increases for pharmaceutical, medical tech, and biopharmaceutical companies, while airline stocks declined, reflecting investor concerns about mpox's global spread.

Endometrial cancer (EC) incidence rises with obesity and reproductive changes. EC is categorized into estrogen-dependent and non-estrogen-dependent types, with symptoms like bleeding and pain. Early diagnosis is crucial, though no established screening exists. Endometrial hyperplasia (EH) is a common disorder due to excessive estrogen, often leading to irregular bleeding and infertility. Hysteroscopy is the gold standard for diagnosing EH, with high sensitivity and specificity. EH and EC frequently coexist, with severe atypical hyperplasia (AH) increasing EC risk. Early detection and intervention in AH improve prognosis. This study analyzed 200 patients, finding age ≥ 53.5 years, menopausal status, and severe AH as high-risk factors for EC. The risk of EC increases with the number of high-risk factors. Despite challenges, improving diagnostic methods and training is essential for better outcomes.

DRC received 99,100 mpox vaccine doses from EU, with 200,000 total doses due by end of week. DRC has recorded over 19,000 cases and 650 deaths. Vaccination campaign to start end of month. Additional 560,000 doses to be given by EU to DRC and other affected countries. DRC faces logistical challenges due to infrastructure and storage requirements.

Africa CDC and WHO launched a $600M, 6-month mpox response plan focusing on surveillance, testing, and community engagement. 55% of funds target 14 affected nations, 45% for operational support. 5,549 cases and 643 deaths reported in 2024, with Congo accounting for 91% of cases. 200,000 mpox vaccines donated by EU arrived in Congo, with 3M needed to curb outbreaks. Vaccination prioritizes close contacts and sex workers, with potential future expansion to children aged 12-17.

Mpox cases in DRC exceed 20,000, with Guinea's first case raising affected countries to 14. Africa CDC and WHO launch a joint response plan. DRC and Burundi report high child infection rates. Kenya confirms its fifth case. CDC research indicates very low risk of mpox transmission during airline travel.

GSK’s Nucala (mepolizumab) significantly reduced moderate and severe COPD exacerbations in the Phase III MATINEE trial. Nucala targets IL-5 to reduce type 2 inflammation, previously approved for eosinophilic asthma and other conditions. The trial involved 806 COPD patients with elevated blood eosinophil counts, adding Nucala or placebo to optimized maintenance therapy. GSK plans to present full MATINEE data at a future congress, aiming to inform regulatory discussions for Nucala’s approval in COPD.

House to fast-track China-related bills to counter U.S. foe, focusing on Chinese spyware, electric vehicles, farmland purchases, WHO pandemic treaties, biotech equipment, Confucius Institutes, and espionage.

The Royal Society of Canada Working Group, in partnership with CIHR, is conducting an international knowledge exchange initiative to develop actionable recommendations for strengthening Canada's health research system post-pandemic. The initiative involves sessions with various stakeholders to gather input on strategies addressing four themes from the WHO research system framework: governance/stewardship, capacity building, financing, and producing/using research. Surveys are used to collect data on organizational strategies, modifications for pandemic recovery, and competing interests, with results informing the development of recommendations.