A recent study highlights the effectiveness and safety of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in managing chronic kidney disease (CKD), showing a significant reduction in the risk of major adverse kidney events (MAKEs) compared to traditional RAAS blockade therapy. The study, conducted in a real-world setting, supports the broader application of SGLT2i in CKD management, regardless of diabetic status, aligning with the 2024 KDIGO guidelines.