Pilot Study of IC14 (Atibuclimab), an Anti-CD14 Monoclonal Antibody, to Treat STEMI
- Conditions
- STEMIStent ImplantationSTEMI (ST Elevation MI)STEMI - ST Elevation Myocardial Infarction (MI)
- Interventions
- Other: Placebo, 150 mL intravenously, once
- First Posted Date
- 2024-11-07
- Last Posted Date
- 2025-02-10
- Lead Sponsor
- Implicit Bioscience
- Target Recruit Count
- 10
- Registration Number
- NCT06678074
- Locations
- 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States
🇺🇸Washington University School of Medicine, Saint Louis, Missouri, United States
IC14 for Treatment of Acute Decompensated Heart Failure
- First Posted Date
- 2024-08-16
- Last Posted Date
- 2025-04-02
- Lead Sponsor
- Implicit Bioscience
- Target Recruit Count
- 10
- Registration Number
- NCT06556810
- Locations
- 🇺🇸
University of Virginia, Charlottesville, Virginia, United States
🇺🇸Virginia Commonwealth University, Richmond, Virginia, United States
Anti-CD14 Treatment with IC14 in Hospitalized ARDS Patients
- Conditions
- Adult Respiratory Distress SyndromeAcute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)Acute Lung InjuryAcute Respiratory Distress Syndrome
- Interventions
- Other: Placebo
- First Posted Date
- 2024-07-22
- Last Posted Date
- 2024-11-07
- Lead Sponsor
- Implicit Bioscience
- Target Recruit Count
- 56
- Registration Number
- NCT06513949
- Locations
- 🇺🇸
University of Washington, Seattle, Washington, United States
IC14 (Atibuclimab) in Arrhythmogenic Cardiomyopathy
- Conditions
- Arrhythmogenic Right Ventricular DysplasiaArrhythmogenic Left Ventricular CardiomyopathyArrhythmogenic Right Ventricular Cardiomyopathy 1Arrhythmogenic CardiomyopathyACMARVCPKP2
- Interventions
- First Posted Date
- 2024-02-23
- Last Posted Date
- 2025-05-11
- Lead Sponsor
- Implicit Bioscience
- Target Recruit Count
- 5
- Registration Number
- NCT06275893
- Locations
- 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States
🇺🇸Cleveland Clinic, Cleveland, Ohio, United States
Compassionate Use Open-Label Anti-CD14 Treatment in Patients With SARS-CoV-2 (COVID-19)
- Conditions
- COVIDARDS, HumanArdsSARS-CoV2
- First Posted Date
- 2020-04-15
- Last Posted Date
- 2021-06-21
- Lead Sponsor
- Implicit Bioscience
- Registration Number
- NCT04346277
- Locations
- 🇮🇹
IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milano, Italy
IC14 for ALS Patients Expanded Access
- Conditions
- Amyotrophic Lateral Sclerosis
- First Posted Date
- 2020-03-16
- Last Posted Date
- 2020-06-24
- Lead Sponsor
- Implicit Bioscience
- Registration Number
- NCT04309604
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
IC14 in Adult Patients With Dengue Fever
- Conditions
- Dengue Fever
- Interventions
- Biological: IC14Drug: Placebo
- First Posted Date
- 2019-03-14
- Last Posted Date
- 2019-03-14
- Lead Sponsor
- Implicit Bioscience
- Registration Number
- NCT03875560
IC14 for Treatment of Amyotrophic Lateral Sclerosis
- Conditions
- Amyotrophic Lateral SclerosisMotor Neuron Disease
- Interventions
- Other: PlaceboBiological: IC14
- First Posted Date
- 2018-04-25
- Last Posted Date
- 2020-05-15
- Lead Sponsor
- Implicit Bioscience
- Registration Number
- NCT03508453
- Locations
- 🇦🇺
Royal Brisbane and Women's Hospital, Herston, Queensland, Australia
Dose-Escalation, Safety and Pharmacokinetic Study of IC14 in Motor Neurone Disease
- Conditions
- Amyotrophic Lateral SclerosisMotor Neuron Disease
- Interventions
- Biological: IC14
- First Posted Date
- 2018-04-04
- Last Posted Date
- 2019-03-14
- Lead Sponsor
- Implicit Bioscience
- Target Recruit Count
- 10
- Registration Number
- NCT03487263
- Locations
- 🇦🇺
Royal Brisbane and Women's Hospital, Herston, Queensland, Australia
IC14 for Rapidly Progressive Amyotrophic Lateral Sclerosis (ALS)
- Conditions
- Amyotrophic Lateral Sclerosis
- First Posted Date
- 2018-03-22
- Last Posted Date
- 2020-06-24
- Lead Sponsor
- Implicit Bioscience
- Registration Number
- NCT03474263
- Locations
- 🇦🇺
Royal Brisbane & Women's Hospital, Herston, Queensland, Australia