Molecular Profiling Reveals Drug Vulnerabilities in Pancreatic Metastases of Renal Cell Carcinoma
• Researchers have identified distinct molecular profiles in pancreatic metastases of clear cell renal cell carcinoma (PM-ccRCC).
• Patient-derived cell cultures (PDCs) from PM-ccRCC exhibit shared drug vulnerabilities, offering potential therapeutic targets.
• Exome and single-cell RNA sequencing revealed unique genetic and transcriptional features of PM-ccRCC compared to primary ccRCC.
• Drug sensitivity testing identified potential therapeutic options for PM-ccRCC, highlighting personalized treatment strategies.
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