McGill University

Epitopea's CryptoMap platform identified 589 non-redundant tumor antigens in cutaneous melanoma and NSCLC, with only 1% derived from mutated sequences.

Clinical trials of VIA Disc NP, a minimally invasive treatment using donor nucleus pulposus tissue, demonstrated significant reduction in chronic back pain from 7.1 to 3.8 on a 10-point scale over 12 months.

• Recent analysis of lecanemab (Leqembi) clinical trial data reveals a 31% difference in drug effectiveness between male and female Alzheimer's patients, with men showing a 43% slowing of cognitive decline compared to just 12% in women. • Researchers from McGill University conducted 10,000 simulated trials based on Phase 3 CLARITY AD data, finding the gender disparity occurred randomly in only 12 simulations, suggesting the difference is statistically meaningful. • The findings have significant implications for clinical practice as two-thirds of Alzheimer's patients are female, highlighting the urgent need for sex-specific considerations in both drug development and treatment decisions.

A comprehensive analysis of 2,730 phase 2 cancer trials shows that one in six patients receives treatments that ultimately gain FDA approval, providing important insights for clinical trial recruitment.