CHILDREN'S HOSPITAL COLORADO

Gates Institute at CU Anschutz had a successful 2024 with groundbreaking research, new scientific advisory board, challenges in cell therapy GMP production, Cheri Adams' career in clinical research, CAR T-cell therapy for solid tumors, Gates Summer Internship Program, 2023 Gates Grubstake Fund recipients, CDMO agreement with Charles River Laboratories, Navin Pinto's role as medical lead, and a new phase 1 CAR T-cell therapy study for pediatric B-ALL patients.

A clinical trial of 4-phenylbutyrate (PBA) shows significant reduction in seizure activity among children with genetic mutations causing severe epilepsy. Some children who failed multiple anti-seizure drugs have become seizure-free. The research is supported by nonprofit patient advocacy organizations, SLC6A1 Connect and Cure GABA-A, founded by mothers of children with genetic epilepsy. The trial is conducted at Vanderbilt University Medical Center, Weill Cornell Medical Center, Children's Hospital Colorado, and the University of Texas Southwestern Medical Center.

Aquestive Therapeutics received positive FDA feedback on its planned NDA submission for Anaphylm (epinephrine) sublingual film, set for early 2025. The FDA agreed with the NDA content and format, endorsed the safety evaluation, and supported the ongoing pediatric trial. No additional adult trials are required, though an advisory committee meeting may precede final decision. Anaphylm could be the first oral epinephrine product for severe allergic reactions, with a projected launch in late 2025 or early 2026.

Becker's 2024 list highlights hospitals & health systems excelling in oncology, recognized for advanced clinical trials & research. Notable institutions include AdventHealth, Allina Health, Arkansas Children's, Atlantic Health System, Banner MD Anderson Cancer Center, Baylor Scott & White Health, Boston Medical Center, Brown University Health, Children's Health, Children's Hospital Colorado, Children’s Hospital Los Angeles, Children’s Hospital of Orange County, Children's Hospital of Philadelphia, Children's Nebraska, ChristianaCare, City of Hope Comprehensive Cancer Center, Cleveland Clinic, Connecticut Children’s, Covenant Health, Dana-Farber Cancer Institute, Dartmouth Health, DeTar Hospital Cancer Center, Duke Health, El Paso Children's Hospital, Emory Healthcare, Endeavor Health, Fred Hutchinson Cancer Center/UW Medicine, Geisinger, Hackensack Meridian Health, Huntsman Cancer Institute at the University of Utah, Inova, Jefferson Health, Johns Hopkins, Jupiter Medical Center, Keck Medicine of USC, Laredo Medical Center, Lehigh Valley Health Network, MUSC Health, MaineHealth, Massachusetts General Hospital, Mayo Clinic, MedStar, MemorialCare, Memorial Sloan Kettering Cancer Center, Michigan Medicine, Mount Sinai Health System, Nebraska Medicine, New York-Presbyterian Hospital-Columbia and Cornell, Northwestern Medicine, Novant Health, OSF HealthCare, OU Health, Ochsner Health, Ohio State University Comprehensive Cancer Center, Oregon Health & Science University Hospital, Orlando Health, Penn Medicine, Providence Alaska Medical Center, Providence Cancer Institute of Oregon, Providence South Division Cancer Institute, Queen's Health System, RWJBarnabas Health and Rutgers Cancer Institute, Renown Health, Rochester Regional Health, Roper St. Francis Healthcare, Roswell Park Comprehensive Cancer Center, Sanford Health, Sarasota Memorial Health Care System, Scripps Health, St. Jude Children's Research Hospital, Stanford Medicine, Stanford Medicine Children's Health, Sutter Health, Swedish Cancer Institute, Sylvester Comprehensive Cancer Center at University of Miami, Tampa General Hospital, Texas Children's Hospital, UC Davis Health, UCLA Health, UCSF Health, UK HealthCare, UNM Health System, UVA Health, UW Health, UMass Memorial Health, University of Alabama Birmingham Hospital, University of Chicago Medical Center, University of Colorado Cancer Center-UCHealth University of Colorado Hospital, University Hospitals, University of Iowa Health Care, University of Kansas Health System, University of Texas MD Anderson Cancer Center, University of Vermont Health Network, Vanderbilt University Medical Center, Virtua Health, WVU Cancer Institute, WellSpan Health, Yale New Haven Health.

The HIMSS Analytics Maturity Assessment Model (AMAM) has been updated to reflect advancements in AI and analytics, focusing on measuring the impact of these technologies on healthcare operations and patient outcomes. The new AMAM emphasizes governance, privacy, security, and fostering a culture of responsible analytics, while addressing potential risks and biases in AI applications. It serves as a strategic roadmap for health systems to refine their data strategies and decision-making processes.

Colorado's MFM division uses telemedicine to provide high-risk pregnancy care, reducing travel and costs for patients and providers.