JEWISH GENERAL HOSPITAL

GLP-1 Receptor Agonists Not Linked to Increased Suicide Risk, Study Finds

5 months ago

• A nationwide study in France found no increased risk of suicide or suicide attempts associated with GLP-1 receptor agonists (GLP-1 RAs). • The research included patients with psychiatric disorders and obesity, addressing a gap in previous clinical trials. • The study used a case-time-control design to account for confounding factors and exposure-trend bias, enhancing the reliability of the findings. • Results showed a negative association between GLP-1 RA use and suicidal behaviors, suggesting short-term psychiatric safety.

Targeted Alpha Therapy: The Next Frontier in Cancer Treatment

6 months ago

• Targeted alpha therapy uses radioactive alpha particles to shred the DNA of cancer cells, proving more potent and less damaging than current treatments. • Clinical trials are underway for various cancers, including pancreatic, prostate, breast, and neuroendocrine, with potential regulatory approval in a few years. • Pharmaceutical companies are heavily investing in targeted alpha therapy, signaling strong belief in its potential with recent deals totaling billions of dollars. • Challenges remain in the widespread availability of targeted alpha therapy, including limited production sites for rare isotopes and high treatment costs.