Ness, Gregory M DDS

Bird flu cases rose to 64 this year, with detections in wastewater and signs of dangerous mutations. Experts warn of potential pandemic risk as the virus spreads among animals and humans, with some cases lacking identified sources of infection.

Psychiatric drugs appear more effective in clinical trials sponsored by manufacturers than in independently funded trials, with sponsor-funded trials reporting 49% higher efficacy and 43% more likely to show statistically significant improvements. Most of the effect is attributed to publication bias, where positive results are more likely to be published. Policy changes, such as mandating the publication of all trial results and ensuring strong ethical oversight, are recommended to mitigate the sponsorship effect.

Alzheimer’s disease research shifts focus from amyloid hypothesis to gene therapy, aiming to convert bad genetics to good in the brain. Researchers use viral vectors to deliver protective genes, like APOE2, to combat Alzheimer’s. Early results show promise, with decreased tau protein levels and no significant adverse events. Challenges include immune response to AAV vectors and therapy affordability.

A study shows bed sores significantly impact motor function recovery and independence in daily activities for spinal cord injury patients, with inflammation and bacterial spread hampering healing.

The U.S. Supreme Court will review FDA's denial of flavored e-cigarette sales by Triton and Vapetasia, citing health risks to youths. The FDA appeals a lower court ruling that the agency did not follow proper legal procedures under the Administrative Procedure Act. The case could impact the FDA's regulatory power and the market availability of e-cigarettes.

Researchers developed a blood-brain barrier-crossing conjugate (BCC) system using γ-secretase-mediated transcytosis to deliver large therapeutic molecules into the brain via intravenous injection, effectively silencing harmful genes in ALS and Alzheimer’s models without significant side effects, potentially revolutionizing treatments for neurological and psychiatric disorders.

GLP-1 weight-loss meds like Ozempic cause increased food waste as appetites falter, but waste declines with medication acclimation. New users report 25% more food waste, with a 30% increase among those using the meds for 90 days or less. Nausea and dietary changes, such as reduced intake of alcohol, pasta, and sweets, contribute to the waste. Long-term users lose an average of 20% of their body weight.

Despite no cure for the common cold, the US Cold & Cough Remedies market is projected to generate $11.19 billion in 2024. The FDA proposed removing phenylephrine, a common but ineffective OTC cold medicine ingredient, after a 17-year petition. Medical experts advise against using phenylephrine alone and recommend nasal saline, honey for cough, and hydration for cold relief. Prevention, including handwashing and avoiding face touching, is emphasized as the best strategy against colds.

Early teacher-student relationships significantly influence academic, social, and emotional development. Strong bonds from kindergarten through third grade benefit child development and learning, with girls more negatively affected by conflict and less closeness. Teachers should encourage open communication and validate emotions to build strong relationships.