Khyber Teaching Hospital

Genetic Variants Influence Amlodipine Response in Pakistani Population, Study Finds

7 months ago

• A pharmacogenomic study in Pakistan reveals that genetic polymorphisms influence the effectiveness of amlodipine, a common hypertension drug. • The study identifies specific variants in genes like CACNA1C and CACNA1D that are associated with better blood pressure control in patients treated with amlodipine. • A variant in the ACE gene was linked to poorer blood pressure control, suggesting that genetic testing could help personalize hypertension treatment. • These findings highlight the potential for pharmacogenomics to improve hypertension management by tailoring drug choices based on individual genetic profiles.