Engineered "Invisible" Brain Cells Reverse Parkinson's Symptoms in Preclinical Study
• Australian researchers have developed human brain cells with an "invisibility cloak" that evades immune detection, successfully restoring muscle function in rat models of Parkinson's disease without requiring immunosuppressant drugs.
• The engineered cells contain eight modified genes that mimic natural immune evasion mechanisms found in placenta and cancer cells, creating a potential "universal" cell line for transplantation across multiple neurological conditions.
• This breakthrough could eliminate the need for anti-rejection medications that increase infection risk and cause tissue damage, representing a significant advancement toward off-the-shelf cell therapies for conditions including Parkinson's, stroke, and Huntington's disease.
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