Clinical Trials
190
52 active
Approvals
0
Total approvals
Agencies
0
Regulatory bodies
Founded
1966
Active, not recruiting
7
3.7%
Completed
70
36.8%
Not yet recruiting
45
23.7%
Recruiting
54
28.4%
Terminated
8
4.2%
Unknown
2
1.1%
Withdrawn
4
2.1%
No approval data available
- A large Australian real-world study of 1,691 patients found younger adults (≤50) with bowel cancer that spread only to the liver differ from older patients in tumor biology, disease characteristics, and survival outcomes. - Younger patients were more likely to be women, have left-sided tumors, and carry certain genetic mutations, and they lived longer overall after liver metastasis. - BRAF and KRAS mutations were associated with poorer outcomes across both age groups, underscoring the growing importance of genetic testing in treatment planning. - Surgery to remove liver tumors followed by drug therapy was linked to better outcomes, though researchers caution the observational design cannot prove causation.
- The CMR GUIDE trial found that implantable cardioverter-defibrillators (ICDs) did not significantly improve the primary endpoint overall in patients with LVEF 36–50% and myocardial scarring. - A prespecified subgroup analysis showed ICD implantation was associated with a 72% reduction in the primary endpoint among patients younger than 70 years. - The secondary endpoint of sudden cardiac death was significantly reduced in the ICD group compared with the implantable loop recorder group (1.7% vs. 5.8%). - Investigators recommend discussing CMR GUIDE data with younger patients during shared decision-making and using the insights to inform larger future trials.
- A study of 107 healthy adults aged 26 to 86 links aging to a "safety-first" walking strategy that prioritizes stability over speed and energy efficiency. - Older adults showed greater ankle co-contraction, stiffening the joint for stability but making muscles work harder without generating as much forward movement. - Reduced push-off power produced shorter strides and slower walking speeds, which may explain greater fatigue and impaired recovery from trips or slips. - Researchers suggest exercise programs emphasize balance, coordination and lower-leg strengthening, such as tai chi, rather than strength alone.
- Flinders University researchers received $9 million from the NHMRC 2026 Centres of Research Excellence grants, split equally across three projects addressing urgent health challenges. - Professor Raymond Chan will lead a $3 million Centre to improve holistic, value-based survivorship care for more than 1.6 million Australians living with cancer. - Associate Professor Courtney Ryder's STRONG Centre will advance Indigenous-led injury prevention and care for Aboriginal and Torres Strait Islander communities, where injury is the third leading cause of death. - Professor James Smith's WellMen Centre will develop strategies to address the mental health and wellbeing crisis among Australian boys and men in schools, sports clubs, and online settings.
- A global consortium of experts argues that toxoplasmosis meets all WHO criteria for classification as a neglected tropical disease (NTD), citing its substantial yet overlooked global health burden. - One third of the world's population is infected with Toxoplasma gondii, and ocular toxoplasmosis is the leading intraocular infection and a major cause of vision loss worldwide. - The most severe outcomes, including blindness and congenital neurological damage, disproportionately affect populations with limited access to healthcare, safe food, clean water, and prenatal care. - Formal NTD recognition would unlock research funding, integrate prevention into maternal and child health programs, and advance coordinated One Health action across human, animal, and environmental sectors.
- A comprehensive qualitative risk assessment published in *Carcinogenesis* finds that nicotine-based e-cigarettes are likely carcinogenic, with consistent evidence across human biomarker studies, animal models, and mechanistic data. - Researchers report that 22.5% of mice exposed to e-cigarette aerosol developed lung adenocarcinomas, while human studies show DNA damage, oxidative stress, and inflammation linked to vaping. - Dual users of both e-cigarettes and conventional cigarettes face a four-fold increased risk of developing lung cancer, according to recent epidemiological evidence from the USA. - The authors warn against repeating the decades-long delay that occurred before smoking was officially recognized as a cause of lung cancer, urging a precautionary approach now.
- Professor Huji Xu received the Flinders University Convocation Medal for pioneering the world-first allogeneic CAR-T cell therapy for autoimmune diseases, which may enable damaged immune systems to be "reset." - His landmark study was the first to use engineered immune cells to target cells mistakenly attacking the body's own tissues, potentially leading to remission in autoimmune disease. - Professor Xu is now focused on developing cost-effective cell therapies that are safer, faster to deliver, and more affordable, citing industrial mass-production as a key advantage of allogeneic CAR-T. - The award was presented among 10 exceptional alumni at a ceremony in Adelaide Town Hall on 28 August, recognising his research into the genetic drivers of autoimmune disease.
- A randomized controlled trial of 15 adults with obstructive sleep apnea found that 50 mg of quetiapine increased total sleep time by more than 40 minutes and reduced wakefulness by 45%. - Despite improved sleep, quetiapine more than tripled attention lapses and slowed reaction times in driving simulator tests the next morning. - Roughly one in four participants did not recognize their own impairment, raising safety concerns for driving and operating machinery. - Researchers recommend avoiding driving for at least 9.5 hours after taking quetiapine and call for larger, longer-term studies before routine off-label use for sleep.
- New research reveals tau protein is essential for organizing and preserving long-term memories by coordinating engram cell activity during learning. - A separate study shows amyloid beta competes with tau for microtubule binding sites, potentially displacing tau and triggering cellular transport breakdown in Alzheimer's. - Controlled tau phosphorylation at T205 helps stabilize memory traces, while disease-associated abnormal tau disrupts both memory formation and retrieval. - Findings suggest future Alzheimer's treatments could target the a-beta/tau interaction on microtubules rather than solely removing protein clumps.
- A comprehensive analysis of 23,211 breast cancer patients from 19 clinical trials found that proton pump inhibitors (PPIs) used for heartburn treatment were associated with 19% higher risk of death and 36% increased risk of serious adverse events. - The study revealed that common cardiovascular medications including beta-blockers and ACE inhibitors increased severe side effects but did not impact overall survival rates. - Researchers emphasize the need for careful medication review in breast cancer patients, as many manage multiple chronic conditions requiring various medications alongside cancer treatment. - The findings highlight potential drug interactions that could compromise cancer treatment effectiveness, though patients should not discontinue medications without medical consultation.
