相关临床试验
163
17 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1903
进行中（未招募）
2
1.2%
已完成
93
57.1%
尚未招募
15
9.2%
招募中
48
29.4%
暂停
3
1.8%
Unknown
2
1.2%
暂无批准数据
- Researchers at Kyushu University identified lipoic acid trisulfide (LASSS), which more than doubles HGF's binding affinity for the c-met receptor while protecting against nitration-induced dysfunction. - The compound appears to induce a structural change in hepatocyte growth factor, creating an enhanced "Super HGF" form that resists the age-related chemical damage underlying muscle wasting. - In a mouse model of muscle atrophy, LASSS pretreatment significantly reduced nitration levels compared with untreated animals, while glutathione trisulfide showed no protective effect. - The findings may support new strategies for preserving muscle repair during aging, prolonged bed rest, and muscle disuse conditions across multiple species including humans.
- A Kyushu University and RIKEN study of 9,605 Japanese adults aged 65+ found that favorable modifiable risk factors significantly lower dementia risk in individuals with zero or one APOE ε4 allele. - Individuals carrying two APOE ε4 alleles (homozygotes) had over 10-fold higher dementia risk than noncarriers, and lifestyle modifications did not significantly alter their risk. - Brain MRI scans showed less brain atrophy and fewer white matter lesions in those with lower modifiable risk scores among one-or-no-allele carriers, but not in two-allele carriers. - Researchers emphasize population-based prevention strategies targeting vascular and lifestyle risk factors, while calling for earlier intervention and novel therapies for high-risk homozygotes.
• A multicenter Japanese study demonstrates that aflibercept using a treat-and-extend regimen maintained baseline visual acuity and significantly reduced central macular thickness in neovascular AMD patients over five years. • Researchers identified smaller greatest linear dimension (GLD) as the only independent risk factor associated with better vision outcomes after five years of treatment (p=0.0024). • The study revealed patients required fewer injections after the first year, though 33% of discontinued cases experienced recurrence, with higher recurrence rates in those who had received more total injections.
