LOUIS STOKES CLEVELAND VA MEDICAL CENTER

Researchers Achieve Complete Alzheimer's Reversal in Mouse Models Through NAD+ Restoration

- Researchers from University Hospitals and Case Western Reserve University successfully reversed advanced Alzheimer's disease in two different mouse models by restoring brain NAD+ levels using compound P7C3-A20. - The study demonstrated that maintaining proper NAD+ balance not only prevented Alzheimer's development but also enabled complete cognitive recovery even after significant disease progression had occurred. - Both mouse models showed normalized blood levels of phosphorylated tau 217, a clinical biomarker of Alzheimer's, providing strong evidence of disease reversal and potential for future human trials. - The findings challenge the century-old belief that Alzheimer's is irreversible and suggest therapeutic strategies targeting brain energy balance could offer a path to disease recovery rather than just prevention or slowing.