Natural Immune Systems Inc.

Single Dose of EpiCor Yeast Postbiotic Triggers Rapid, Selective Anti-Inflammatory Cytokine Changes in Healthy Adults

- A randomized, double-blind, placebo-controlled crossover trial in 30 healthy adults found a single 500-mg dose of the yeast-derived postbiotic EpiCor rapidly modulated inflammatory cytokines within 1–3 hours. - IFN-γ and IL-1ra fell significantly at 1 hour, while IL-4, IL-7, and IL-8 declined significantly at 2 hours, with downward trends for IL-1β, IL-5, and TNF-α. - The changes reflected targeted modulation of specific inflammatory pathways rather than broad immune suppression, accompanied by transient redistribution of CD25-positive immune cell subsets. - Researchers hypothesize the rapid response may involve gut–brain neuroimmune and vagal signaling, though the mechanism remains unproven and requires further study.