Shenzhen Children's Hospital

Novel Selenium-Enhanced Exosome Therapy Shows Promise for Traumatic CNS Injuries

- Researchers from the Chinese Academy of Sciences developed SeNExo, a novel therapeutic agent combining neural stem cell-derived exosomes with ultrasmall nano-selenium particles for treating traumatic brain and spinal cord injuries. - The therapy effectively crosses the blood-brain barrier via APOE-LRP-1 interaction and addresses both oxidative damage through ROS scavenging and neuronal repair through exosome-mediated mechanisms. - In mouse models, SeNExo reduced cerebral lesions, improved spatial learning and memory functions in TBI, and promoted locomotor recovery in spinal cord injury cases. - The treatment demonstrates significant potential by downregulating oxidative stress and apoptosis genes while promoting glial homeostasis and enhancing neuron-glia communication networks.