Part of Caris Life Sciences, LLC
Clinical Trials
838
67 active
Approvals
0
Total approvals
Agencies
0
Regulatory bodies
Founded
1921
Active, not recruiting
47
5.6%
Completed
487
58.1%
Enrolling By Invitation
9
1.1%
No Longer Available
1
0.1%
Not yet recruiting
11
1.3%
Recruiting
105
12.5%
Suspended
1
0.1%
Terminated
108
12.9%
Unknown
10
1.2%
Withdrawn
59
7.0%
No approval data available
- A multidisciplinary team from Cleveland Clinic, RIKEN and IBM advanced to the finals of the 2026 ACM Gordon Bell Prize for simulating the largest biologically meaningful molecules ever modeled with quantum computers, reaching 12,635 atoms. - The work unites quantum and classical computing in a quantum-centric supercomputing framework, using up to 94 qubits and nearly 6,000 quantum operations alongside the Fugaku and Miyabi-G supercomputers. - The team scaled its method roughly 40-fold and achieved a 210-fold improvement in accuracy within a year, while improving computed binding energies relevant to predicting drug–protein interactions. - The 2026 Gordon Bell Prize winner will be announced at SC26 in Chicago, Nov. 15–20, 2026.
- A 5-year-old Alabama boy with Wiskott-Aldrich Syndrome, a rare X-linked genetic condition, met the bone marrow donor who saved his life for the first time. - Genetic testing at Children's of Alabama confirmed the diagnosis after the boy presented with low platelet count and nephrotic syndrome. - The boy underwent chemotherapy followed by a bone marrow transplant at age 3, enduring seven months of hospitalization and severe complications before recovery. - Children's of Alabama reports that 18,000 patients are diagnosed annually with life-threatening blood cancers or diseases for which a blood stem cell transplant may be their best hope for a cure.
- Red and near-infrared light penetrate deeper into skin than other wavelengths and appear to boost cellular energy and collagen production, but evidence for at-home devices remains limited. - A manufacturer-funded trial of 59 middle-aged adults found 86% of combination laser-and-LED mask users had slight crow's feet reduction versus 17% with a placebo mask. - Experts say safety data for red-light therapy is stronger than efficacy data, and people with photosensitive disorders or light-sensitizing medications should avoid it. - Dermatologists advise checking FDA clearance, disclosed device specifications, and eye protection, and caution that sunscreen and tretinoin likely offer better returns.
- Cleveland Clinic opened two new research buildings totaling 300,000 square feet at E. 100th Street and Cedar Avenue, representing the largest research investment in the organization's more than 100-year history. - The facilities house more than 700 employees and nearly 30 laboratories and core service areas, including the Sheikha Fatima bint Mubarak Global Center for Pathogen & Human Health Research. - The $400 million complex anchors the $500 million Cleveland Innovation District, a public-private initiative targeting 20,000 jobs and $3 billion in regional economic impact by 2030. - The expansion supports infectious disease, virology, cancer immunotherapy, and high-performance computational research, including the on-campus IBM Quantum System One.
- A Virginia physician woke to find a bat attempting to enter her mouth, prompting immediate emergency evaluation and rabies testing that ultimately returned negative. - Bats are the leading source of human rabies in the U.S., causing at least 7 out of 10 rabies fatalities, with two-thirds of annual rabies shots linked to bat exposure. - Experts advise that any direct physical contact with a bat, especially waking in a room with one, should be treated as a high-risk exposure requiring prompt medical assessment. - Post-exposure prophylaxis should begin as soon as possible after exposure, though rabies is considered a medical urgency rather than an emergency because infection spread takes days.
- Tadalafil (Cialis), a PDE-5 inhibitor used for erectile dysfunction, is increasingly promoted in wellness circles as a longevity drug with cardiovascular, cognitive, and performance benefits. - Observational studies show sizable associations: a 55% lower rate of cardiovascular death and 44% lower overall mortality among over 8,000 men, plus a 32% lower dementia risk in a study of over half a million patients. - Experts caution that these retrospective findings show association, not causation, and emphasize the need for randomized controlled trials before routine clinical use. - The Princeton Consensus Panel recently reached consensus that low-dose tadalafil is "appropriate" for a subset of men at elevated cardiovascular risk, though formal recommendations remain unpublished.
- A new NASPGHAN position paper endorses therapeutic drug monitoring (TDM) as a key strategy to optimize biologic therapies and improve outcomes in pediatric inflammatory bowel disease. - Proactive TDM during induction decreases the likelihood of suboptimal drug levels, which can raise the risk of anti-drug antibody development and reduce medication effectiveness. - Only four biologic therapies are FDA-approved for children, underscoring the need to optimize efficacy rather than "burn through" limited treatment options. - Higher drug concentrations during induction correlate with favorable outcomes, while suboptimal levels at Week 14 are linked to higher anti-drug antibody risk and poorer response.
- A novel AI model developed through the Cleveland Clinic-IBM Discovery Accelerator identifies hidden sleep patterns linked to heart disease, cognitive decline, and death from routine polysomnography data. - Patients in the highest-risk group had twice the five-year mortality risk compared to the lowest-risk group, a distinction not captured by the standard apnea-hypopnea index. - The model performed well for both men and women, addressing a known limitation of the apnea-hypopnea index which historically performs better in men. - Findings, published in Nature Communications and validated in a nationwide cohort, suggest routine medical tests may contain substantially more physiological information than current clinical practice extracts.
- Siemens Healthineers and Cleveland Clinic expand their 35-year relationship through a new 10-year strategic alliance focused on clinical and workflow innovation across the health system. - The alliance will deliver advanced diagnostic imaging and therapeutic technologies including MRI, CT, radiation oncology, interventional radiology, and X-ray, supported by an expanded on-site team of over 30 employees. - A key initiative includes supporting Cleveland Clinic's development of a theranostics cancer-treatment program that combines targeted imaging and therapy to personalize cancer care. - The collaboration builds on more than 100 research projects and 70 peer-reviewed publications, with additional focus on MRI technologist education and workforce development in the Cleveland region.
- Cleveland Clinic researchers found elevated blood levels of TMAO, a gut bacteria byproduct from red meat digestion, are linked to higher atrial fibrillation risk. - The study analyzed blood samples from over 5,000 patients undergoing heart procedures and conducted laboratory studies to understand TMAO's mechanism. - TMAO changes the heart's electrical environment, increasing susceptibility to abnormal rhythms, suggesting dietary intervention may offer earlier prevention opportunities. - Atrial fibrillation affects at least 2.7 million Americans, and TMAO testing is now widely available and incorporated into clinical practice.
