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- MassBiologics of UMass Medical School has initiated the first human clinical trial of Lyme PrEP, a pre-exposure prophylaxis using a single monoclonal antibody that could prevent Lyme disease. - The trial has enrolled 66 volunteers in Nebraska to evaluate safety and pharmacology, with researchers hoping to determine how long the protective antibody remains in circulation after administration. - Unlike traditional vaccines, Lyme PrEP provides immediate protection upon injection and targets Borrelia bacteria in tick guts before transmission, potentially offering a solution to a disease that affects approximately 476,000 Americans annually.
