MZRW Advanced Drug Monograph

Medication Report: MZRW

Name: MZRW Name (English): MZRW (also known as Ma Zi Ren Wan or Hemp Seed Pill)

Description: MZRW is a traditional Chinese medicine (TCM) formula composed of six herbs: Huo Ma Ren (Fructus Cannabis), Da Huang (Radix et Rhizoma Rhei), Bai Shao (Radix Paeoniae Alba), Xing Ren (Semen Armeniacae Amarum), Zhi Shi (Fructus Aurantii Immaturus), and Hou Pu (Cortex Magnoliae Officinalis).

Traditional Uses: In TCM, MZRW has been used for centuries to treat constipation by moistening the intestines, draining heat, and promoting the movement of Qi.

Purported Uses and Benefits:

• Constipation: Clinical studies suggest MZRW is effective in treating functional constipation by increasing complete spontaneous bowel movements, improving colonic transit, and reducing symptoms such as straining, incomplete evacuation, and bloating. Some studies indicate a sustained effect even after treatment cessation.
• Other potential uses: Some research explores its use in constipation related to specific conditions or treatments, such as in elderly patients, women, and potentially in cancer patients.

Side Effects: Reported side effects may include abdominal pain, cramping, bloating, nausea, vomiting, headache, diarrhea, gas, and dizziness.

Drug Interactions: Herbal formulas can interact with other medications. Consultation with a healthcare provider is advised before use.

Clinical Evidence:

• Randomized controlled trials (RCTs) have shown MZRW to be more effective than placebo in treating functional constipation in Asian populations.
• Some studies indicate comparable efficacy to senna, a common laxative, with potentially more sustained effects.
• Network pharmacology studies suggest that MZRW's active components enhance colonic motility through multiple targets and pathways.
• Research suggests MZRW may improve bowel movement by down-regulating oleamide levels.

Important Note: Much of the clinical data available is focused on Asian populations. More well-designed trials are needed to strengthen the evidence base and determine its effectiveness in diverse populations and for non-functional constipation.