adsorbed tetanus vaccine Advanced Drug Monograph

Adsorbed Tetanus Vaccine Report

Name: adsorbed tetanus vaccine Name (English): adsorbed tetanus vaccine

Indication: Active immunization against tetanus. Often combined with other vaccines like diphtheria and/or pertussis.

Mechanism of Action: Contains tetanus toxoid, which is inactivated tetanus toxin. It works by stimulating the body's immune system to produce antibodies against tetanus toxin, providing protection against tetanus infection. The "adsorbed" form means the toxoid is attached to an aluminum salt, which enhances the immune response.

Dosage and Administration: Administered via intramuscular injection. The primary series typically consists of three doses, followed by booster doses every 10 years. Dosage and schedule may vary based on age and specific vaccine formulation.

Contraindications: Severe allergic reaction to a previous dose of tetanus vaccine or any component of the vaccine. Certain neurological conditions may also be contraindications.

Warnings and Precautions:

• Guillain-Barré Syndrome following a previous tetanus toxoid-containing vaccine.
• Moderate or severe acute illness.
• Latex allergy (for some formulations with latex stoppers).
• Immunosuppression may reduce the immune response.

Adverse Reactions:

• Local: Pain, redness, swelling at the injection site.
• Systemic: Mild fever, irritability, drowsiness, loss of appetite. Severe reactions are rare but can include allergic reactions (hives, difficulty breathing, swelling), high fever, and neurological complications.

Drug Interactions: Immunosuppressive therapies may reduce the effectiveness of the vaccine.

Storage: Store refrigerated between 2°C and 8°C (36°F and 46°F). Do not freeze.

Presentation: Available as a suspension for injection in single-dose or multi-dose vials.

Manufacturer: Varies depending on the specific product and region.

Regulatory Status: Licensed for use in Taiwan. Specific formulations and manufacturers may have different regulatory approvals.

Note: This report provides general information. Always consult the specific product information leaflet and a healthcare professional for detailed guidance on adsorbed tetanus vaccine use.