RLY-2608 Shows Promise in PI3Kα-Mutated HR+/HER2- Breast Cancer
Updated clinical data on RLY-2608 plus fulvestrant will be presented at the San Antonio Breast Cancer Symposium, showcasing its efficacy in advanced breast cancer.
AI Chatbot Trial Aims to Boost Cervical Cancer Screening Participation
An IARC-led randomized controlled trial is evaluating an AI-powered chatbot to increase cervical cancer screening among women.
BeiGene's Brukinsa and Novel Assets Show Promise in CLL Treatment at ASH 2024
BRUKINSA demonstrated a 71% reduction in progression or death risk compared to bendamustine-rituximab in treatment-naïve CLL patients over a 5-year follow-up.
Osimertinib and Ramucirumab Combination Shows Promise in EGFR-Mutated NSCLC
A Phase II trial (RAMOSE) demonstrated that combining osimertinib and ramucirumab significantly prolonged progression-free survival (PFS) in patients with EGFR-mutant, TKI-naïve NSCLC.
Arvinas and Pfizer's Vepdegestrant Plus Abemaciclib Shows Promise in Breast Cancer Trial
Preliminary Phase 1b data of vepdegestrant with abemaciclib shows a 62.5% clinical benefit rate in advanced breast cancer patients previously treated with CDK4/6 inhibitors.
Stem Cell-Derived Therapy Trial Enrolls First Michigan Patient for Drug-Resistant Epilepsy
Wayne State University enrolled the first Michigan patient in a Phase I/II trial testing stem cell-derived interneuron implantation to reduce seizure frequency.
Eli Lilly Aims to Launch Tirzepatide in India by 2025, Pending Regulatory Approval
Eli Lilly plans to launch tirzepatide, known as Mounjaro and Zepbound, in India by 2025 for diabetes and obesity treatment, pending regulatory approvals.
Ribociclib Shows Favorable Safety Profile and Maintained Efficacy with Dose Reduction in HR+ Early Breast Cancer
The NATALEE trial demonstrated that ribociclib, at a 400-mg dose, presents a manageable safety profile for patients with HR+ early breast cancer, with neutropenia being the most common toxicity.
Phase 3 ProstACT GLOBAL Trial Assesses 177Lu-TLX591 in Metastatic Castration-Resistant Prostate Cancer
The ProstACT GLOBAL trial is evaluating 177Lu-TLX591 plus standard of care (SOC) versus SOC alone in metastatic castration-resistant prostate cancer (mCRPC) patients.
SHR-1701 Plus Famitinib Shows Promise in Advanced Biliary Tract and Pancreatic Cancer
Combination therapy with SHR-1701 and famitinib demonstrates encouraging objective response rates in biliary tract cancer (BTC) and pancreatic ductal adenocarcinoma (PDAC) patients.
Disitamab Vedotin Shows Promise in HER2-Positive Breast Cancer with Liver Metastasis
Disitamab Vedotin (DV) significantly improved progression-free survival (PFS) compared to Lapatinib plus Capecitabine in HER2-positive advanced breast cancer with liver metastasis.
Novartis' Intrathecal Zolgensma Shows Positive Phase III Results for SMA Type 2
Novartis' intrathecal onasemnogene abeparvovec (OAV101 IT) met its primary endpoint in the Phase III STEER study for SMA Type 2.
CGM Use Improves Glycemic Control in Type 2 Diabetes Patients Not on Bolus Insulin
A study of type 2 diabetes patients not on bolus insulin showed that continuous glucose monitoring (CGM) significantly improved glycemic control compared to standard care.
European Commission Approves Imetelstat for Transfusion-Dependent Anemia in Lower-Risk MDS
The European Commission has granted marketing authorization for imetelstat (Rytelo) as the first telomerase inhibitor approved for transfusion-dependent anemia in lower-risk myelodysplastic syndrome patients ineligible for or unresponsive to erythropoietin-based therapy.
Fezolinetant and Elinzanetant Effectively Reduce Vasomotor Symptoms in Menopausal Women
A meta-analysis of seven RCTs demonstrates that fezolinetant and elinzanetant significantly reduce the frequency of vasomotor symptoms in menopausal women.
Novel Clinical Trial Tests Benzodiazepine Agonist Treatment vs. Tapering for Dependency in OAT Patients
A groundbreaking clinical trial is investigating the effectiveness of stabilizing benzodiazepine agonist treatment compared to standard tapering for patients with benzodiazepine dependence in opioid agonist treatment (OAT) programs. The 26-week study will evaluate treatment outcomes across multiple Norwegian OAT clinics, with a primary focus on reducing illicit benzodiazepine use.
Empagliflozin May Slow Diabetic Retinopathy Progression in Type 2 Diabetes
A recent study indicates that empagliflozin is associated with a 22% lower risk of diabetic retinopathy progression in type 2 diabetes patients.
Psilocybin-Assisted Therapy Shows Promise for Mental Health in Cancer Patients and Alcohol Use Disorder
Psilocybin-assisted psychotherapy significantly reduced anxiety, depression, and other psychological distress in cancer patients, with benefits lasting up to six months.
Switching from Entecavir to Tenofovir Alafenamide Shows Similar Efficacy in Chronic Hepatitis B
A recent study found that switching from entecavir (ETV) to tenofovir alafenamide (TAF) in chronic hepatitis B patients showed similar effects on serum HBsAg levels over 240 weeks.