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A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy

Phase 1
Recruiting
Conditions
Recurrent Childhood Acute Myeloid Leukemia
Recurrent Childhood Myelodysplastic Syndrome
Recurrent Juvenile Myelomonocytic Leukemia
Refractory Childhood Acute Myeloid Leukemia
Refractory Childhood Myelodysplastic Syndrome
Refractory Juvenile Myelomonocytic Leukemia
Interventions
Procedure: Biospecimen Collection
Procedure: Bone Marrow Aspiration
Procedure: Bone Marrow Biopsy
Drug: Cytarabine
Procedure: Echocardiography
Drug: Fludarabine
Drug: Hydrocortisone Sodium Succinate
Biological: Imetelstat
Drug: Leucovorin Calcium
Procedure: Lumbar Puncture
Drug: Methotrexate
First Posted Date
2024-02-08
Last Posted Date
2024-12-04
Lead Sponsor
Children's Oncology Group
Target Recruit Count
36
Registration Number
NCT06247787
Locations
🇺🇸

Children's Hospital Colorado, Aurora, Colorado, United States

🇺🇸

C S Mott Children's Hospital, Ann Arbor, Michigan, United States

🇺🇸

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

and more 10 locations
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