ESTEEM After Stroke Program Launches Phase III Trial to Enhance Stroke Recovery
The ESTEEM After Stroke program, a Phase III trial funded by the Medical Research Future Fund, is testing a community-based approach combining exercise, socialization, and cognitive activities to improve recovery and quality of life for stroke survivors. This innovative program, led by researchers from Hunter New England Local Health District, HMRI, and the University of Newcastle, aims to validate the effectiveness of environmental enrichment in stroke rehabilitation.
MDMA Rejection for PTSD Treatment Could Fuel Black Market Demand, Expert Warns
An FDA advisory panel rejected MDMA-assisted therapy for PTSD, citing concerns about trial design, abuse potential, and psychotherapy roles.
STRIDE Regimen Demonstrates Doubled 5-Year Survival in Unresectable Hepatocellular Carcinoma
The STRIDE regimen (durvalumab plus tremelimumab) shows a significant 5-year survival benefit in patients with unresectable hepatocellular carcinoma (uHCC).
Rocket Pharma Completes Enrollment in Phase 2 Trial of RP-A501 for Danon Disease
Rocket Pharmaceuticals has completed enrollment in its Phase 2 pivotal trial of RP-A501 for male patients with Danon disease.
INmune Bio's AD02 Phase 2 Trial Shows EMACC Correlation with CDR-SB in Alzheimer's
INmune Bio's AD02 Phase 2 trial data shows a highly significant correlation (p<0.001) between EMACC and CDR-SB, a key endpoint in Alzheimer's trials.
Apnimed's AD109 Phase 3 Trial for Obstructive Sleep Apnea Completes Enrollment
Apnimed has completed enrollment for its Phase 3 SynAIRgy study evaluating AD109, a potential oral treatment for obstructive sleep apnea (OSA).
Cassava Sciences' Simufilam Maintains Safety Profile in Phase 3 Alzheimer's Trials
An independent Data and Safety Monitoring Board (DSMB) has endorsed the continuation of Cassava Sciences' Phase 3 trials for simufilam in Alzheimer's disease.
Dyadic Coping Intervention Shows Promise for Stroke Recovery
A randomized controlled trial is underway to assess the effectiveness of the Dyadic Coping Intervention of Social Participation (DCISP) for stroke survivors and their spouses.
SIFI Receives European Patent for Polihexanide and Launches AKANTIOR® in Germany
SIFI's patent for polihexanide covers its formulation and use in treating Acanthamoeba keratitis and fungal keratitis, providing IP protection until 2040.
Individualized PEEP Guided by Lung Ultrasound Reduces Atelectasis After Colorectal Surgery
A randomized controlled trial demonstrated that ultrasound-guided individualized positive end-expiratory pressure (PEEP) reduces postoperative atelectasis severity in patients undergoing laparoscopic colorectal cancer resection.
Scilex Presents Data on GLOPERBA® for Gout Flare Prophylaxis in Renally Impaired Patients
Scilex Holding Company presented data on GLOPERBA® (colchicine oral solution) at the 2024 American College of Rheumatology Convergence conference.
Infigratinib Shows Promise in Phase 2 Trial for Achondroplasia
Infigratinib, an oral FGFR3 inhibitor, significantly increased annualized height velocity in children with achondroplasia in a Phase 2 trial.
Sana Biotechnology Faces Investigation Over Program Suspension and Stock Drop
Pomerantz Law Firm is investigating Sana Biotechnology for potential securities fraud related to the suspension of its SC291 and SC379 programs.
Toripalimab Plus Chemotherapy Shows Promise in Advanced Pancreatic Cancer
A phase Ib/II study reveals that toripalimab combined with gemcitabine and nab-paclitaxel (GnP) demonstrates promising efficacy in patients with advanced pancreatic ductal adenocarcinoma (PDAC).
Wearable Sensor Validated as Primary Endpoint for Duchenne Muscular Dystrophy Trials
A wearable sensor measuring stride velocity (SV95C) has been validated as a primary endpoint for clinical trials in ambulatory Duchenne Muscular Dystrophy (DMD).
Kira Pharmaceuticals' KP104 Shows Sustained Efficacy and Safety in PNH Phase 2 Trial
KP104, a dual-targeting complement inhibitor, demonstrates long-term safety and efficacy in complement inhibitor-naïve PNH patients.
Amlodipine and Candesartan Combination Therapy Shows Superior Efficacy in Treating Hypertension
A Phase III clinical trial demonstrates that a combination of amlodipine and candesartan is more effective than amlodipine alone in reducing diastolic blood pressure in hypertensive patients.
Difamilast Shows Comparable Efficacy and Safety to Delgocitinib in Atopic Dermatitis: A Matching-Adjusted Indirect Comparison
A matching-adjusted indirect comparison (MAIC) study suggests difamilast 1% cream has comparable efficacy and safety to delgocitinib in treating moderate-to-severe atopic dermatitis (AD).
Ketamine and Psilocybin: Meta-Analysis Reveals Correlation Between Subjective Effects and Therapeutic Outcomes
A new meta-analysis explores the relationship between the subjective experiences induced by ketamine and psilocybin and their antidepressant effects.