Flexible Representation of Speech in the Supratemporal Plane
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Supratemporal Neural Response to Change in Acoustic-Phonetic Dimensions
研究概览
简要总结
The overarching goal of this exploratory research is to understand the dynamic and flexible nature of speech processing in the human supratemporal plane. The temporal lobe has long been established as a region of interest in the speech perception and processing literature because it contains the auditory cortex. More recently, research has localized the supratemporal plane as an area that exhibits response specificity to acoustic properties of complex auditory signals like speech. The supratemporal plane, comprised of Heschl's gyrus, the planum polare, and the planum temporale, is capable of the rapid spectrotemporal analysis required to map acoustic information to linguistic representation. Neural activity in this area, however, is rarely studied directly because it is difficult to access with non-invasive measures like scalp electroencephalography (EEG). Capitalizing on the unique opportunity to access these areas via routine clinical stereoelectroencephalography (sEEG) in a patient population, this study seeks to understand how cortical responses reflect the diagnosticity of two acoustic-phonetic dimensions of interest and how responses rapidly and flexibly adapt to changes in listening demands. Examining how neural response to voice onset time (VOT) and fundamental frequency (F0) modulates as a function of perceptual weight carried in signaling phoneme categories, and identifying how changes in listening context shift perceptual weight, will provide invaluable data that indicates how speech processing flexibly adapts to short-term acoustic patterns.
详细描述
The purpose of this study is to understand the dynamic, flexible nature of speech processing as a function of perceptual weight applied to acoustic-phonetic dimensions within varying listening contexts and demands.
The specific aims of this study are as follows:
- To establish the neural response to two acoustic-phonetic dimensions as a function of the perceptual weight they carry when signaling phoneme identity.
Aim 1 will specifically evaluate responses to voice onset time (VOT) and fundamental frequency (F0). Data collected will provide a baseline response for participants. 2. To identify how experimental manipulation of listening context impacts perceptual weighting strategies of VOT and F0.
Aim 2 will evaluate modulation of neural response to the introduction of noise and the introduction of an "accent."
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 15 Years 至 25 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals 15-25 years old
- •Undergoing sEEG placement in the supratemporal plane for clinically necessary localization of epileptic foci or language mapping
- •Fluent English speakers
- •Cognition and speech-language skills within normal limits (as determined by evaluation prior to surgery)
- •Normal or correct-to-normal visual acuity
- •Normal hearing acuity in each ear (as determined by audiometric assessment)
- •No history of autism or ADHD
排除标准
- •Individuals with intellectual disabilities
- •Abnormal epileptiform activity in the supratemporal plane
- •Lack of fluent English comprehension/production
- •Severe language or auditory-specific cognitive dysfunction
- •History of autism or ADHD
结局指标
主要结局
Supratemporal Neural Response to Change in Acoustic-Phonetic Dimensions
时间窗: During sEEG-EEG recording sessions, up to 3 hours total
Neural activity will be measured via simultaneous EEG-sEEG monitoring in the supratemporal plane as indicated by high-gamma band activity in the electrical signal. Neural activity will be measured as participants listen to acoustic stimuli with gradually manipulated acoustic dimensions, fundamental frequency (F0) and voice onset time (VOT). The data reported here is the number of temporal lobe channels demonstrating significant encoding of change in acoustic dimension (F0 as VOT is held constant).
Behavioral Impact of Change in Acoustic-Phonetic Dimensions
时间窗: During sEEG-EEG recording sessions, up to 3 hours total
Behavioral responses in the form of a category judgment will be obtained as participants listen to acoustic stimuli in with gradually varying fundamental frequency (F0) and voice onset time (VOT). Participants will provide a behavioral response by indicating the phoneme perceived at the beginning of stimulus words (/b/ or /p/). Specifically, the outcome is reported as percent of stimuli classified as /p/ over varying F0 with VOT held constant.
Supratemporal Neural Response to Change in Listening Context
时间窗: During sEEG-EEG recording sessions, up to 3 hours total
Neural activity was measured via sEEG monitoring as indicated by high-gamma band activity in the electrical signal. Neural activity will be measured as participants listen to acoustic stimuli in accented speech. The un-transformed voltage represents the difference in electric potential between a specific electrode contact and the reference electrode contact; since we use a common average reference, that means it's the difference between a specific electrode contact and the mean voltage across all electrodes. We then z-score to characterize shifts from baseline activity (where z = 0) at a specific electrode, which is believed to measure changes in voltage due largely to post-synaptic currents. This is a mathematical transformation rather than a published scale or standardized assessment. More extreme z-scores (+ or -) indicate a greater change from baseline local neural activity; in other words, stimuli evoked greater activity in this region.
Behavioral Impact of Change in Listening Context
时间窗: During sEEG-EEG recording sessions, up to 3 hours total
Behavioral responses in the form of a category judgment will be obtained as participants listen to acoustic stimuli in a varied listening context: accented speech. Participants will provide a behavioral response by indicating the phoneme perceived at the beginning of stimulus words (/b/ or /p/). Specifically, the outcome is reported as the mean % of stimuli classified as /p/ with varying VOT and F0 relationships.
Supratemporal Neural Response to Change in Acoustic-Phonetic Dimensions
时间窗: During sEEG-EEG recording sessions, up to 3 hours total
Neural activity will be measured via simultaneous EEG-sEEG monitoring in the supratemporal plane as indicated by high-gamma band activity in the electrical signal. Neural activity will be measured as participants listen to acoustic stimuli with gradually manipulated acoustic dimensions, fundamental frequency (F0) and voice onset time (VOT). The data reported here is the number of temporal lobe channels demonstrating significant encoding of change in acoustic dimension (F0 as VOT is held constant).
Behavioral Impact of Change in Acoustic-Phonetic Dimensions
时间窗: During sEEG-EEG recording sessions, up to 3 hours total
Behavioral responses in the form of a category judgment will be obtained as participants listen to acoustic stimuli in with gradually varying fundamental frequency (F0) and voice onset time (VOT). Participants will provide a behavioral response by indicating the phoneme perceived at the beginning of stimulus words (/b/ or /p/). Specifically, the outcome is reported as percent of stimuli classified as /p/ over varying F0 with VOT held constant.
Supratemporal Neural Response to Change in Listening Context
时间窗: During sEEG-EEG recording sessions, up to 3 hours total
Neural activity was measured via sEEG monitoring as indicated by high-gamma band activity in the electrical signal. Neural activity will be measured as participants listen to acoustic stimuli in accented speech. The un-transformed voltage represents the difference in electric potential between a specific electrode contact and the reference electrode contact; since we use a common average reference, that means it's the difference between a specific electrode contact and the mean voltage across all electrodes. We then z-score to characterize shifts from baseline activity (where z = 0) at a specific electrode, which is believed to measure changes in voltage due largely to post-synaptic currents. This is a mathematical transformation rather than a published scale or standardized assessment. More extreme z-scores (+ or -) indicate a greater change from baseline local neural activity; in other words, stimuli evoked greater activity in this region.
Behavioral Impact of Change in Listening Context
时间窗: During sEEG-EEG recording sessions, up to 3 hours total
Behavioral responses in the form of a category judgment will be obtained as participants listen to acoustic stimuli in a varied listening context: accented speech. Participants will provide a behavioral response by indicating the phoneme perceived at the beginning of stimulus words (/b/ or /p/). Specifically, the outcome is reported as the mean % of stimuli classified as /p/ with varying VOT and F0 relationships.
次要结局
- Neural Response of Non-Regions of Interest to Change in Listening Context(During sEEG-EEG recording sessions, up to 3 hours total)
- Neural Response of Non-Regions of Interest to Change in Acoustic-Dimension(During sEEG-EEG recording sessions, up to 3 hours total)
- Neural Response of Non-Regions of Interest to Change in Listening Context(During sEEG-EEG recording sessions, up to 3 hours total)
研究者
Taylor Abel
Assistant Professor of Neurological Surgery; Pediatric Neurosurgeon
University of Pittsburgh