NCT00742118已完成不适用
Effects of the Soluble Mediators of Mastocytes on the Intestinal Epithelial Barrier and of the entérique Nervous System During the Syndrome of the Irritable Bowel
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Para-cellular permeability
研究概览
简要总结
Patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. The investigators aimed to investigate:
- paracellular permeability in colonic biopsies of IBS patient
- the ability of soluble factors from colonic biopsies to reproduce in vitro these alterations
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients needing coloscopy
排除标准
- •Disrupted coagulation results
- •Cancer even healed
- •Known food allergy.
- •Alcohol consumption >30g/day
研究组 & 干预措施
2
Experimental
patient with chronic inflammatory intestinal disease
干预措施: Colic biopsies (Procedure)
3
Other
patient having no symptoms
干预措施: Colic biopsies (Procedure)
1
Experimental
patient with irritable bowel syndrome
干预措施: Colic biopsies (Procedure)
结局指标
主要结局
Para-cellular permeability
时间窗: at time=0
Inflammation molecule expression
时间窗: at time=0
Gap junction protein expression
时间窗: at time=0
Digestive discomfort degree
时间窗: at time=0
次要结局
未报告次要终点
研究者
研究点 (2)
Loading locations...
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