ISRCTN03869290已完成未知
Effect of spironolactone on exercise capacity in older people without heart failure: a double-blind placebo-controlled trial
niversity of Dundee (UK)0 个研究点目标入组 120 人开始时间: 2008年8月21日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 120
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged 65 years and over, either sex
- •2. Self-reported problems with activities of daily living
排除标准
- •1. A clinical diagnosis of symptomatic heart failure according to the Economic and Social Research Council (ESRC) criteria
- •2. Asymptomatic left ventricular systolic dysfunction
- •3. Already taking spironolactone
- •4. On angiotensin converting enzyme inhibitor or angiotensin receptor blocker
- •5. Systolic blood pressure less than 100 mmHg
- •6. Serum potassium greater than 5.0 mmol/l
- •7. Serum sodium less than 130 mmol/l
- •8. Creatinine greater than 200 umol/l
- •9. Estimated glomerular filtration rate (eGFR) less than 30 ml
- •10. Addison's disease
- •11. Previous reported intolerance of spironolactone
- •12. Cognitive impairment precluding informed consent
- •13. Wheelchair bound
- •14. Unwilling to participate
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