Truth or Dare; Artificial Blastocoel Collapse of Human Blastocysts Before Vitrification
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- survival rate
研究概览
简要总结
: This prospective randomized observational study aimed to compare behavior of artificially collapsed blastocysts to blastocysts that were vitrified without artificial collapse.
详细描述
One arm study of 60 patients with sibling blastocysts divided into 2 groups: Study group (artificially laser-collapsed blastocysts; n=71) & control group (blastocysts were vitrified without laser collapse; n=66) then reexpansion speed and survival rate was assessed immediately & at 140 min after thawing and compared between two groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
盲法说明
only the investigator knew the procedure provided for each case
入排标准
- 年龄范围
- 20 Years 至 37 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age limit 20-37 At least 6 good quality blastocysts per case. expansion rate 3-4
排除标准
- •bad quality blastocysts expansion rate less than 3
研究组 & 干预措施
Study group (artificially laser-collapsed blastocysts)
laser was used as an intervention before blastocyst vitrification to assist rapid blastocyst collapse with vitrification
干预措施: laser assisted collapse (Device)
& control group (blastocysts were vitrified, no laser collapse
blastocyst were vitrified without laser assisted collapse
结局指标
主要结局
survival rate
时间窗: 140 min after thawing
survival rate will be assessed at 140 minutes after thawing and compared between both groups.
survival rate
时间窗: immediately after thawing
survival rate will be assessed immediately after thawing and compared between both groups.
次要结局
未报告次要终点
研究者
Ahmed Saad
Assistant professor of Obstetrics & Gynecology
Benha University