Effectiveness of Repeated Amiodarone Dosing Regimen Versus Standard Dosing Regimen in Atrial Fibrillation Patient With Rapid Ventricular Response
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Heart rate
研究概览
简要总结
The goal of this clinical trial is to compare in atrial fibrillation patient with rapid ventricular response. The main question it aims to answer are Effectiveness of Repeated Amiodarone dosing regimen versus standard dosing regimen in Atrial fibrillation patient with rapid ventricular response Participants will receive Amiodarone iv treatment with different regimen
- Repeated dosing regimen
- Standard dosing regimen
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age above 18 years old
- •Atrial fibrillation with rapid ventricular response patient (ventricular rate > 110)
排除标准
- •Baseline EKG Corrected QT interval (QTc) < 500 msec
- •History of pulmonary fibrosis
- •History of Cirrhosis
- •Cardiac Index <2.2 L/min/m2 or Cardiogenic shock
- •Unstable arrhythmia
- •Receive amiodarone within 3 months prior to present illness
- •Pregnancy
- •Amiodarone or Iodine allergy
研究组 & 干预措施
Repeated amiodarone bolus dosing regimen
An Initial 150 mg IV amiodarone bolus should be given over a 15-minute period. If the heart rate is still over 110 minutes after the initial treatment, provide an additional 150 mg IV amiodarone bolus over a 15-minute period. During the first 24 hours, this bolus may be administered up to three times in total. Within 24 hours of finishing the first bolus dosage, 900 mg of amiodarone will be administered intravenously.
干预措施: Amiodarone (Drug)
Standard dosing regimen
An Initial 150 mg IV amiodarone bolus should be given over a 15-minute period, then a 24-hour amiodarone loading infusion 900 mg over 24 hours
干预措施: Amiodarone (Drug)
结局指标
主要结局
Heart rate
时间窗: 6-hours after receiving amiodarone bolus
Percentage of patients who have Atrial fibrillation with rapid ventricular response, the percentage of patients who have heart rate below 110 bpms at 6 hours after receiving a repeated amiodarone bolus and loading dose regimen to the percentage of patients who have heart rate below 110 bpms at 6 hour after a conventional amiodarone IV loading dose regimen
次要结局
- Heart rate(24-hours after receiving amiodarone bolus)
- Major adverse cardiovascular events(30 days after receiving amiodarone bolus)
- Phlebitis(24-hours after receiving amiodarone bolus)
- Normal sinus rhythm at 24 hours(24-hours after receiving amiodarone bolus)
- Changed in heart rate(24-hours after receiving amiodarone bolus)
研究者
Chawit Lopimpisuth
Principal Investigator
Police General Hospital, Thailand