The Cancer Genome Atlas and Recurrence Risk Prediction of East Asian Breast Cancer: a Multicenter Collaborative Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 2,000
- 试验地点
- 1
- 主要终点
- Prevalence of unique genetic alterations
研究概览
简要总结
This project aims to establish the cancer genome atlas and the platform of recurrence risk prediction specific for East Asian breast cancer patients. The study was planned to collect blood sample, fresh tumor tissue, and paraffin embedded tumor tissue from 2000 patients. Aims to identify unique genetic alterations in Asian tumors, to identify the susceptible genes for breast carcinogenesis in East Asia, and to establish the new platform for accurate prediction of recurrence. The investigator will explore the association of patient outcomes with the genetic alterations from the cancer atlas of East Asian breast tumors.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged more than 20-year-old at the time of informed consent.
- •An unconfirmed breast tumor, or have histologically confirmed invasive breast cancer.
- •Have radiological or objective evidence of breast tumor size ≥1 cm.
- •Be able to comply with study procedures to collect the clinical medical information, blood sample, fresh tumor tissue, and 12 sections of paraffin embedded tumor tissue.
- •Be able to sign an informed consent.
排除标准
- •Have histologically confirmed ductal carcinoma in situ (DCIS).
- •Stage I, II or III breast cancer patients who have received neoadjuvant treatments, including chemotherapy, hormonal therapy, or targeted therapy.
- •Stage IV or metastatic breast cancer patients who have received chemotherapy.
结局指标
主要结局
Prevalence of unique genetic alterations
时间窗: 3 years
To establish the cancer genome atlas and identify the susceptible genes for breast carcinogenesis in East Asia
次要结局
- Recurrence rate(10 years)