Placental miRNA (microRNA) Profile in Fetal Overgrowth Related to Maternal Obesity Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 82
- 试验地点
- 1
- 主要终点
- Fetal Overgrowth
研究概览
简要总结
The purpose of this study is to determine whether placental and umbilical cord blood miRNA expression is altered in women with obesity with macrosomic neonates to when compared to miRNA expression from control patients.
详细描述
MicroRNA's are a class of non-coding RNA's that function as translational repressors and are thought to modulate tissue development, proliferation, differentiation and function. Differential expression of certain placental miRNA's has been associated with preeclampsia.
The fetal origins of adult disease hypothesis suggests that risk factors from intrauterine environmental exposures affect the fetus' development during sensitive periods, and increases the risk of specific diseases in adult life. Our aim is to understand factors that predispose fetuses to fetal overgrowth in utero, especially in women with obesity. The objective of the study is to identify miRNA which are differentially expressed in the placenta and cord blood of pregnancies that are affected by fetal macrosomia to determine factors that may predispose fetuses to fetal overgrowth.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •singleton pregnancy
- •prenatal care & delivery at the Hospital of the University of Pennsylvania system
- •Normal glucose tolerance test results (less than 120 mg/dl)
排除标准
- •Multiple gestation
- •under 18 years old, or over 45 years old
- •chronic hypertension
- •preeclampsia
- •chronic steroid use
- •major fetal anomaly
- •connective tissue disorder requiring medication
- •active HIV
- •Hepatitis C
结局指标
主要结局
Fetal Overgrowth
时间窗: Delivery date to up to 6 weeks post partum
Placental and cord blood samples will be studied for miRNA expression. The objective of the study is to identify miRNA which are differentially expressed in the placenta and cord blood of pregnancies that are affected by fetal macrosomia to determine factors that may predispose fetuses to fetal overgrowth.
次要结局
未报告次要终点
研究者
Celeste Durnwald
Assistant Professor, Maternal Fetal Medicine, Department of Obstetrics and Gynecology Director, Penn Perinatal Diabetes Program Director, High Risk Clinic at the Helen O. Dickens Center for Women's Health
University of Pennsylvania