EUCTR2018-001755-12-GB进行中（未招募）1 期
A pilot double-blind, randomised, placebo-controlled, cross-over study of metformin to reduce airway glucose in stable COPD - A pilot study of metformin to reduce airway glucose in COPD
Imperial College0 个研究点目标入组 40 人开始时间: 2019年4月23日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
入选标准
- •Age 40 - 75 years
- •A clinical diagnosis of COPD confirmed with spirometry (Post-bronchodilator FEV1/FVC <70%).
- •A smoking history of at least 15 pack years
- •Absence of infection for at least 8 weeks prior to study entry
- •No use of antibiotics and oral corticosteroids at least 8 weeks prior to study entry
- •Able to understand and consent to the study procedures
- •Are the trial subjects under 18? no
- •Number of subjects for this age range: 0
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 20
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 20
排除标准
- •Diagnosis of diabetes irrespective of treatment
- •Diabetes diagnosed on screening bloods
- •History of hepatic or renal impairment
- •Hepatic or renal impairment diagnosed on screening bloods
- •Excessive alcohol intake (>21 units/week)
- •BMI < 18.5kg/m2
- •Taking metformin irrespective of indication
- •History of allergy or hypersensitivity to metformin
- •Pregnancy or breastfeeding
- •Unable to provide informed consent
研究者
相似试验
已完成
不适用
A pilot, double-blind, randomised, placebo-controlled, exploratory study to investigate the safety and effect of calf intestinal Alkaline Phosphatase in patients with SEPsisInfections and InfestationsOther and unspecified infectious diseasesSepsisISRCTN49482187AM-Pharma B.V. (Netherlands)32
已完成
Unknown
A pilot randomized, double-blind, placebo-controlled, parallel-group clinical study to study the safety and tolerability of IP in healthy adultsCTRI/2023/03/050853Vedic Lifesciences Pvt Ltd64
进行中（未招募）
1 期
Study to define the optimal dose, to evaluate efficacy, safety and tolerability of self- administered subcutaneous diclofenac sodium 25-50-75mg/1ml in the treatment of an acute migraine attack with headache.Acute migraine attacks with headache.MedDRA version: 20.0Level: SOCClassification code 10029205Term: Nervous system disordersSystem Organ Class: 10029205 - Nervous system disordersEUCTR2017-004828-29-ITIBSA INSTITUT BIOCHIMIQUE SA128
进行中（未招募）
不适用
A pilot clinical study in kidney transplant to assess the efficacy and safety of cardiotrophin-1.Kidney transplantation.MedDRA version: 14.1Level: LLTClassification code 10023438Term: Kidney transplantSystem Organ Class: 10042613 - Surgical and medical proceduresEUCTR2011-004223-12-ESDigna Biotech S.L.
进行中（未招募）
不适用
A pilot, randomized, double-blind, placebo-controlled, parallel group, multicentre, phase IIa study to determine the clinical safety/tolerability and exploratory efficacy of EHT 0202 (40 and 80 mg bid) as adjunctive therapy to acetylcholinesterase inhibitor over a 3-month period in ambulatory patients suffering from mild to moderate Alzheimer’s Disease (EHT 0202/002 protocol).EUCTR2007-005549-39-FREXONHIT