Effect of DPP4 Inhibitors on Coronary Atherosclerosis in Patients With Diabetes Mellitus on Insulin Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4,007
- 试验地点
- 1
- 主要终点
- Prevalence of obstructive coronary disease
研究概览
简要总结
The study aim is to evaluate whether DPP4-inhibitor could reduce coronary atherosclerosis assessed by CT scan in patients receiving insulin for diabetes mellitus. In this retrospective study, changes in obstructive coronary artery disease prevalence and coronary calcium burden between two coronary CT scans will be compared in patients with and without receiving DPP4-inhibitor.
详细描述
This is a retrospective study using medical records in two hospitals affiliated to the Catholic University of Korea. Patients with diabetes mellitus who received insulin are retrospectively enrolled. Among those, only patients who underwent coronary CT scan for more than two times will be included. Included patients will be classified into DPP4-inhibitor group and no DPP4-inhibitor group according to the prescribed medication. The changes in obstructive coronary artery disease prevalence and coronary calcium score per one year will be compared between the two groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diabetes mellitus
- •Receiving chronic insulin therapy (prescription of insulin pen)
- •Who underwent more than 2 times of coronary CT scan
排除标准
- 未提供
研究组 & 干预措施
DPP4-inhibitor
Patients who were prescribed DPP4-inhibitor during the period between two coronary CT scan.
干预措施: DPP4-inhibitor (Drug)
No DPP4-inhibitor
Patients who were not prescribed DPP4-inhibitor during the period between two coronary CT scan.
干预措施: No DPP4-inhibitor (Drug)
结局指标
主要结局
Prevalence of obstructive coronary disease
时间窗: one year
Change in the prevalence of obstructive coronary disease, defined as \>50 percent stenosis in coronary CT scan
次要结局
- Change in coronary calcium score(one year)
研究者
Sang Hyun Ihm, MD PhD
Professor
The Catholic University of Korea