Quantification of Nerve Stiffness in Patients With Peripheral Neuropathies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- nerve shear wave velocity
研究概览
简要总结
This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography. Patients will be compared with age-matched controls.
详细描述
The following nerve will be studied bilaterally, in a randomised order: Median, ulnar, Radial, Sciatic and Tibial.
Participants will be asked to remain relaxed during elastography measurements.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female aged 18 to 65
- •Having social insurance status
- •Having given informed consent
- •Diagnostic of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), CMT1a or Anti-MAG (peak immunoglobulin M (IGm)>15,000 BTU)
排除标准
- •For controls:
- •Person staying in a health or social facility
- •Person unable to understand the protocol and to respect the modalities
- •Person deprived of liberty
- •Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
- •Participation in another biomedical research in progress
- •Diabetes, history of neuromuscular disease
- •Person staying in a health or social facility
- •Person unable to understand the protocol and to respect the modalities
- •Person deprived of liberty
- •Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
- •Participation in another biomedical research in progress
- •MRC score < 3
- •For Charcot-Marie-Tooth type 1 (CMT1) and anti-MAG:
- •Person staying in a health or social facility
- •Person unable to understand the protocol and to respect the modalities
- •Person deprived of liberty
- •Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
- •Participation in another biomedical research in progress
研究组 & 干预措施
patients with peripheral neuropathies
This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography. Patients will be compared with age-matched controls.
干预措施: elastography measurements (Other)
controls
干预措施: elastography measurements (Other)
结局指标
主要结局
nerve shear wave velocity
时间窗: Day0
Ultrasound shear wave elastography will provide a measure of nerve shear wave velocity, which will be used as a surrogate of nerve stiffness.
次要结局
未报告次要终点