NCT02876653已完成不适用
Accelerated Aging in Middle-Aged Men With Sleep-disordered Breathing.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 2
- 主要终点
- Telomere length of circulating leukocytes
研究概览
简要总结
Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Telomere length of circulating leukocytes
时间窗: 4 weeks
次要结局
- Carotid-femoral pulse wave velocity(4 weeks)
- Markers of oxidative stress: Malondialdehyde, heme oxygenase-1(4 weeks)
- Markers of growth hormone axis (GH, IGF-1, IGFBP)(4 weeks)
- Bone density(4 weeks)
- Correlation between biological parameters and neuropsychological assessment(4 weeks)
- Markers of inflammation: hs-CRP, IL-6, IL-8, MCP-1(4 weeks)
研究者
研究点 (2)
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