NCT04019470撤回不适用
Immunomodulation Analysis on Peripheral Blood Mononuclear Cells of Radiation Therapy in Pediatric Malignant Brain Tumors
Capital Medical University1 个研究点 分布在 1 个国家开始时间: 2019年2月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- The changes of peripheral blood immune cells
研究概览
简要总结
To investigate the effect of radiotherapy on peripheral blood immune cell composition and function in pediatric malignant brain tumor patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 3 to 18
- •To be diagnosed with malignant brain tumors
- •To eligible for radiation therapy
- •Karnofsky performance status ≥ 70
- •No prior radiation exposure
- •Informed consent signed for blood sample collection and used for research purpose
排除标准
- •Patients had received radiotherapy previously.
- •Patients who had no histological diagnosis
- •Patients who do not wish to participate
- •Patients with infections
结局指标
主要结局
The changes of peripheral blood immune cells
时间窗: 6 weeks (prior and post the radiation therapy )
The flow cytometric analysis of lymphocyte subtypes populations would be performed
次要结局
- The changs of inflammatory cytokines and chemokines(6 weeks (prior and post the radiation therapy ))
- Activation status of T cells(6 weeks (prior and post the radiation therapy ))
研究者
Jun Ren MD, PhD
Cancer Center Director
Capital Medical University
研究点 (1)
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