The Impact of Using Cold Irrigation on Postoperative Endodontic Pain and Substance P Level: a Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- Level of post operative pain
研究概览
简要总结
The aim of this clinical trial is to evaluate the effect of using intra-radicular cryotherapy technique in the form of irrigation with cold sodium hypochlorite
The main questions to answer are:
- Does Postoperative pain is different between the three groups?
- Does level of substance P different between the three groups ?
详细描述
- The patients will be randomly divided into three groups Group 1: control group (n=25) Regular root canal treatment with regular irrigant will be used. Group 2: (n=25) Intraradicular cryotherapy will be performed where :
- Normal root canal treatment will be done with irrigation using sodium hypochlorite cooled to 2°C continuously during our mechanical instrumentation. Then a final flush will be done with cold saline 2°C for 5 minutes. Group 3: (n=25) Normal root canal treatment will be done with irrigation using sodium hypochlorite at room temperature during our mechanical instrumentation. Then a final flush will be done with cold saline 2°C for 5 minutes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients that will be diagnosed with symptomatic apical periodontitis
- •Single-rooted premolars (radiographically and clinically assessed)
- •Medically free patients.
- •Teeth with mature apex
排除标准
- •Patients with other pulpal diagnosis.
- •Medically compromised patients.
- •Pregnant females.
- •Patients taking analgesics or anti-inflammatory drugs.
研究组 & 干预措施
Control Group
Conventional root canal treatment is done and irrigation will be done with 2.5% room temperature sodium hypochlorite
Cryotherapy Group
Root canal treatment is done and irrigation is done with cooled sodium hypochlorite ( 2- 4°C) through out the visits and final flush with 2- 4°C cold saline will be used for 5 minutes.
干预措施: cryotherapy (Other)
Final Flush group
Root canal treatment is done and irrigation is done with sodium hypochlorite at room temperature through out the visits then final flush with 2- 4°C cold saline will be used for 5 minutes.
干预措施: cryotherapy (Other)
结局指标
主要结局
Level of post operative pain
时间窗: after 6 hours, 24 hours, 48 hours, 72 hours
On visual analogue scale (VAS) questionnaire, patients will report their level of pain 0° refers for no pain, and the 100° degree refers for unbearable pain
次要结局
- Level of substance P(After access cavity, after finishing mechanical perpetration, before obturation(after 3 days))
研究者
Maram Obeid
Professor of Endodontics
Ain Shams University