ASS-Nonresponse Following Cardiac Surgery as Assessed With Multiple Electrode Aggregometry
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 400
- 试验地点
- 2
- 主要终点
- ASPItest
研究概览
简要总结
It is the aim of the present study to assess the prevalence of ASS-Nonresponse following cardiac surgery using the Multiple Electrode Aggregometry (MEA).
详细描述
Up to now there are no data concerning the prevalence of ASS-Nonresponse following surgical coronary revascularization procedures as assessed with the Multiple Electrode Aggregometry. Results of the present observational study are needed to assess the prevalence of ASS-Nonresponse in order to perform a sample size analysis for a prospective interventional study in a second step.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients older than 18 years after cardiac surgery
- •Antiaggregatory therapy with aspirin postoperatively
排除标准
- •known allergy to aspirin
- •need for an antiaggregatory therapy other than aspirin
- •pregnancy
结局指标
主要结局
ASPItest
时间窗: at day 3 and 5 after the first dose of aspirin following surgery
Area under the aggregation curve following stimulation with arachidonic acid in the Multiple Electrode Aggregometry (MEA)
次要结局
- TRAPtest(at day 3 and 5 after the first dose of aspirin following surgery)
- Platelet Count(at day 3 and 5 after the first dose of aspirin following surgery)
- Myocardial infarction(12 month)
- Mortality(12 month)
- Readmission to hospital(12 month)
研究者
Christian F. Weber, MD
Dr.med. Dr.med. habil Christian F. Weber
Goethe University