Association Between Gastroesophageal Reflux Disease (GERD) Severity and Dental Caries: A Cross-Sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Decayed, Missing, and Filled Teeth (DMFT) Index
研究概览
简要总结
This study aimed to assess the relationship between gastroesophageal reflux disease (GERD) severity (based on upper gastrointestinal endoscopy) and dental caries severity.
详细描述
Gastroesophageal reflux disease (GERD) is a chronic condition characterized by reflux of stomach acid into the esophagus, with a prevalence reaching 20-30% in many populations. Beyond its gastrointestinal manifestations, GERD may have extraesophageal effects, including oral health disturbances such as dental erosion and caries. Exposure of the oral cavity to gastric acid, especially in patients with severe or nocturnal reflux, may contribute to enamel demineralization, increased tooth decay, and lower salivary pH.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-65 years.
- •Both sexes.
- •Diagnosed with Gastroesophageal Reflux Disease (GERD) by endoscopy.
- •Consent to participate.
排除标准
- •Xerostomia-related disorders.
- •Recent antibiotics (last 4 weeks).
- •Head/neck radiation history.
- •Cognitive impairment affecting consent.
- •Pregnant or lactating women.
- •HbA1c above 6.4%.
结局指标
主要结局
Decayed, Missing, and Filled Teeth (DMFT) Index
时间窗: 3 months post-procedure
The Decayed, Missing, and Filled Teeth (DMFT) Index was calculated as the sum of decayed, missing, and filled teeth, with scores ranging from 0 to 28 or 32, depending on the total number of teeth present.
次要结局
- Basic Erosive Wear Examination Index(3 months post-procedure)
- Plaque Index(3 months post-procedure)
- Salivary analysis(3 months post-procedure)
研究者
Mohamed Abd El-Raouf Tawfik
Professor of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University