Prediction Of Cognition Impairment In Elderly Type 2 Diabetes Mellitus Patients With Cardiac Autonomic Neuropathy.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
研究概览
简要总结
This prospective cross-sectional study aims to predict cognitive impairment in individuals with Type 2 Diabetes Mellitus (T2DM) with Cardiac Autonomic Neuropathy (CAN). Cognitive dysfunction is increasingly recognized as a significant but underdiagnosed complication in diabetes, particularly in patients with autonomic dysfunction.Participants with T2DM will be assessed for the presence of CAN using heart rate variability (HRV)based autonomic function testing. Cognitive function will be evaluated using standardized cognitive assessment tools. Multimodal predictors including HRV parameters, eventrelated potentials (P300), sleep quality (Pittsburgh Sleep Quality Index), and physical activity levels (Physical Activity Scale for the Elderly) will be analyzed.The study aims to identify significant predictors of cognitive impairment and develop a predictive model using multivariate regression analysis. Early identification of high risk individuals may facilitate timely intervention and help prevent progression to dementia in this vulnerable population.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 60.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Group With Cognitively Normal Participants Age between 60 to 75 years Diagnosed with Type 2 Diabetes Mellitus T2DM for greater than 1year HbA1c greater than 6.5 percent Presence of Cardiac Autonomic Neuropathy CAN MoCA score greater than 26 Group With Mild to Moderate Cognitive Impairment Age between 60 to 75 years Diagnosed with Type 2 Diabetes Mellitus T2DM for 1year HbA1c greater than 6.5percent Presence of Cardiac Autonomic Neuropathy CAN MoCA score 23 to 26.
排除标准
- •Group A Cognitively Normal Participants MoCA score below 26 Any diagnosed neurological or psychiatric illness Regular use of cognition altering medications History of substance or alcohol abuse Presence of sleep disorders Group B Mild to Moderate Cognitive Impairment MoCA score below 21 severe impairment History of stroke or major CNS disorder not related to diabetes Diagnosed major depression or psychosis Use of drugs that interfere with autonomic or cognitive testing Inability to follow instructions or cooperate during assessments.
研究者
Hina Gul
CPRS,Jamia Millia Islamia