Bioavailability of Potassium From Potatoes and Potassium Gluconate
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- Bioavailability of Potassium
研究概览
简要总结
This study is designed to compare the effect of sources of potassium on uptake and the effect of potassium on blood pressure.
详细描述
The study will compare uptake of potassium from three different doses and sources; supplements (720, 1440 and 2160 mg) potatoes (720, 1440 and 2160 mg) or French fries (2160 mg).
During 9 phases, participants will consume a controlled diet with the supplements, potato or french fries (every other week for 5 days). On the 4th day, blood and urine samples will be taken to monitor potassium uptake and excretion. Measures of blood pressure will be analyzed at defined time points throughout the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to adhere to the visit schedule, protocol requirements and available to complete the study
- •Normotensive men and women
- •Aged 20-60 years
- •BMI of 15-35
排除标准
- •Medication to treat hypertension or hypotension
- •Medication known to affect electrolyte metabolism or contain high levels of potassium or sodium
- •smoke cigarettes or use illegal drugs
- •Hypertension or hypotension
- •Diseases known to affect potassium metabolism
- •Allergic to nuts
研究组 & 干预措施
Placebo control
Subjects will consume tablets containing no potassium in addition to a basal diet containing 2336 mg potassium
干预措施: Placebo control (Dietary Supplement)
Low dose potassium gluconate
Subjects will consume 720 mg potassium in the form of potassium gluconate tablets daily in addition to a basal diet containing 2336 mg potassium
干预措施: Low dose potassium gluconate (Dietary Supplement)
Medium dose potassium gluconate
Subjects will consume 1440 mg potassium in the form of potassium gluconate tablets daily in addition to a basal diet containing 2336 mg potassium
干预措施: Medium dose potassium gluconate (Dietary Supplement)
High dose potassium gluconate
Subjects will consume 2160 mg potassium in the form of potassium gluconate tablets daily in addition to a basal diet containing 2336 mg potassium
干预措施: High dose potassium gluconate (Dietary Supplement)
Low dose potato
Subjects will consume 720 mg potassium in the form of potato daily in addition to a basal diet containing 2336 mg potassium
干预措施: Low dose potato (Dietary Supplement)
High dose potato
Subjects will consume 2160 mg potassium in the form of potato daily in addition to a basal diet containing 2336 mg potassium
干预措施: High dose potato (Dietary Supplement)
Medium dose potato
Subjects will consume 1440 mg potassium in the form of potato daily in addition to a basal diet containing 2336 mg potassium
干预措施: Medium dose potato (Dietary Supplement)
High dose French fries
Subjects will consume 2160 mg potassium in the form of french fries daily in addition to a basal diet containing 2336 mg potassium
干预措施: High dose French fries (Dietary Supplement)
Basal diet control
Subjects will consume a basal diet containing 2336 mg potassium daily
干预措施: Basal diet control (Dietary Supplement)
结局指标
主要结局
Bioavailability of Potassium
时间窗: 5 days
After 4 days of acclimation to the supplementation, absorption of potassium will be measured.
次要结局
- Blood Pressure Response to Potassium(6 days)
研究者
Berdine Martin
Research Scientist
Purdue University