Efficacy and Safety of Zenagamtide s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Obesity (AMAZE 7)

Novo Nordisk A/S46 个研究点分布在 1 个国家目标入组 650 人开始时间: 2026年9月22日最近更新: 2026年8月25日

适应症

试验速览

阶段: 3 期
状态: 尚未招募
发起方: Novo Nordisk A/S
入组人数: 650
试验地点: 46

研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

盲法说明

Sponsor staff involved in the clinical trial is masked according to company standard procedures.

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Male or female (sex at birth).
•Age 18 years or above at the time of signing the informed consent.

排除标准

•Glycated haemoglobin (HbA1c) ≥ 6.5% (48 millimoles per mole [mmol/mol]) as measured by the central laboratory at screening.
•History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
•Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues within 1 year before screening.

研究者

发起方

Novo Nordisk A/S

申办方类型

Industry

责任方

Sponsor

研究点 (46)

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