Effect of White Potatoes on Glycemic Response, Satiety and Food Intake in Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Ad libitum food intake (lunch, at 120 minutes)
研究概览
简要总结
The purpose of the present study is to explore the influence of cooking methods on post-prandial glycaemia and its impact on satiety in children.
详细描述
Each of the 5 study sessions will be at least 7 days apart. Either meal skipping, or one of three treatments of white potatoes (a) baked (with skin), (b) mashed, (c) fried French fries, or white bread, prepared on the day of testing, will be served to healthy children (9-14 years). Participants will consume the equivalent to 1 medium sized potato (~280 kcal) or an equivalent amount of calories from white bread. Glycemic response, insulin, incretin hormones (glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP)), dipeptidyl peptidase 4 (DPP4), and cholecystokinin (CCK) will be measured for 2 h (0, 15, 30, 45, 60, 90 and 120 min) following meal consumption, as well as mood and subjective appetite. An ad libitum test meal will be provided at 120 min to assess food intake suppression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 9 Years 至 14 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •be between 9 and 14 years of age
- •be healthy, and have been born at term
- •be a native English speaker
- •not be taking any medications
- •not have allergies to potatoes, rice, or beans.
- •normal body weight (between the 5th and 85th BMI percentile for age and gender)
排除标准
- •anyone with food sensitivities or allergies to potatoes or potato-products,
- •diabetic or overweight/obese individuals.
结局指标
主要结局
Ad libitum food intake (lunch, at 120 minutes)
时间窗: at 120 minutes post morning meal consumption
Food intake will be determined by weighing the meal before and after serving. The net weight of the test meal will be converted to calories
Change from baseline glycemic response
时间窗: 15, 30, 45, 60, 90, and 120 minutes after meal consumption
Blood glucose (mmol/L). Blood glucose will be measured in whole blood using YSI 2300 STAT PLUS (YSI Incorporated, Yellow Springs, OH)
Change from baseline insulin
时间窗: 15, 30, 45, 60, 90, and 120 minutes after meal consumption
Blood insulin (pmol/L). Insulin concentration in serum will be determined in duplicate via enzyme-linked immunosorbent assay kits (ELISA; Millipore, Billerica, Massachusetts).
次要结局
- Change from baseline mood(15, 30, 45, 60, 90, and 120 minutes after meal consumption)
- Change from baseline subjective appetite(15, 30, 45, 60, 90, and 120 minutes after meal consumption)
- Change from baseline glucose-dependent insulinotropic peptide (GIP)(15, 30, 45, 60, 90, and 120 minutes after meal consumption)
- Change from baseline glucagon-like peptide-1 (GLP-1)(15, 30, 45, 60, 90, and 120 minutes after meal consumption)
- Change from baseline cholecystokinin (CCK)(15, 30, 45, 60, 90, and 120 minutes after meal consumption)
- Change from baseline dipeptidyl peptidase 4 (DPP4)(15, 30, 45, 60, 90, and 120 minutes after meal consumption)
研究者
Nick Bellissimo
Associate Professor
Toronto Metropolitan University