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临床试验/NCT01971229
NCT01971229已完成不适用

Assessment of Insulin Response Following Ingestion of a Carbohydrate/Whey Protein Drink. A Cross-over Randomized Double Blind Study.

Franco Carli2 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2013年12月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
15
试验地点
2
主要终点
Insulin response to a test meal

研究概览

简要总结

Surgery is a stress on the body and recovering well after surgery is very important to patients and their doctors. It is therefore important to prepare patient's bodies for the stress of surgery, and one way to do this is to provide proper nutrition. In the past, patients were asked to prepare for surgery by fasting from midnight before surgery. Today, it is known that this practice is not beneficial to patient's recovery. In fact, it has been recognized that drinking a sugary beverage (e.g., juice) before surgery stimulates the production of insulin, which is a hormone that helps make the proteins needed for wound healing after surgery. This is currently practiced at the MUHC. It might also be beneficial, however, to drink a beverage that contains sugar and whey proteins (a protein isolated from milk) before surgery. In fact, whey proteins stimulate insulin and may also have the added benefit of improving muscular strength. In this study, investigators will measure the level of insulin produced after drinking a carbohydrate (i.e., sugar)-whey protein beverage to determine how it compares to the level of insulin produced after drinking the sugary beverage used at the MUHC.

详细描述

It is hypothesized that the increase in plasma insulin following a mixed carbohydrate whey protein drink is significantly greater than that elicited by a carbohydrate drink.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Double (Participant, Investigator)

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Healthy volunteer

排除标准

  • diabetes,
  • neurological disorders
  • chronic kidney failure
  • chronic liver disease
  • disorders of gastric motility
  • gastro-esophageal reflux
  • achalasia
  • gastroparesis
  • intestinal obstruction
  • previous abdominal surgery
  • lactose intolerance
  • body mass index below 17 or above 29
  • allergy to acetaminophen.

研究组 & 干预措施

Carbohydrate

Sham Comparator

Patients in this arm will drink a 425 mL 100% clear apple juice (carbohydrate 50 g, 700 mOsmol). 1.5 g of acetaminophen will be dissolved in the beverage for determination of gastric emptying.

干预措施: Carbohydrate based drink (Other)

Carbohydrate

Sham Comparator

Patients in this arm will drink a 425 mL 100% clear apple juice (carbohydrate 50 g, 700 mOsmol). 1.5 g of acetaminophen will be dissolved in the beverage for determination of gastric emptying.

干预措施: Whey protein based drink (Other)

Whey Protein

Active Comparator

Patients in this arm will drink a 330 mL Boost fruit flavoured clear beverage (whey protein 12.2 g, carbohydrate 50 g, 700 mOsmol).1.5 g of acetaminophen will be dissolved in the beverage for determination of gastric emptying.

干预措施: Carbohydrate based drink (Other)

Whey Protein

Active Comparator

Patients in this arm will drink a 330 mL Boost fruit flavoured clear beverage (whey protein 12.2 g, carbohydrate 50 g, 700 mOsmol).1.5 g of acetaminophen will be dissolved in the beverage for determination of gastric emptying.

干预措施: Whey protein based drink (Other)

结局指标

主要结局

Insulin response to a test meal

时间窗: Change over 3 hours

Patients will consume a carbohydrate or a whey protein based drink and their insulin response will be monitored every 30 minutes for 3 hours.

次要结局

  • Gastric emptying(Change over 3 hours)

研究者

发起方
Franco Carli
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Franco Carli

Professor, Department of Anesthesia

McGill University Health Centre/Research Institute of the McGill University Health Centre

研究点 (2)

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