CTRI/2020/03/023957招募中未知
Prospective randomised trial for 6-months versus 9-months anti-microbial therapy for tubercular posterior uveitis
Hyderabad Eye Resesarch Foundation0 个研究点目标入组 0 人开始时间: 待定最近更新:
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1.Symptoms ï?£3 months
- •Objective evidence of active intraocular inflammation compatible with TPU
- •e.g. active retinal vasculitis (with FA leakage) or choroidal lesions
- •2. Positive results of tuberculin skin test (TST, ï?³10 mm induration after 48 hours with 5TU) and/or interferon gamma release assay (Quantiferon TB Gold or T-SPOT)
- •3. May have evidence of healed pulmonary or other TB (but not requiring ATT for that disease)
- •4. Age >18 years, not pregnant or willing to use double contraception
排除标准
- •Ophthalmic findings or ancillary test results consistent with non-TB diagnosis
- •Objective findings showing only non-active disease eg. occluded retinal vessels only, with no FA leakage from non-occluded vessels, or atrophic/scarred choroidal lesions
- •1.Optic nerve involvement
- •2.Past history of uveitis
- •3.Previous ATT for ocular or other disease
- •4.Concurrent active pulmonary or other TB disease requiring ATT for that disease.
- •5.HIV infection and other immunocompromised patients
- •6.Treated with systemic or local corticosteroids within 3 months prior to entry
- •7.Received anti-VEGF injections within 3 months prior to entry
- •8.Age less than 18 years
- •9.Pregnancy
- •10.Liver disease
- •11.Likelihood of poor compliance/ refusal to participate in study
研究者
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