NCT01132053已完成不适用
Role of Inflammation in PML
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 126
- 试验地点
- 1
研究概览
简要总结
This is a continuation of our previous studies on Progressive Multifocal Leukoencephalopathy (PML). We will focus on the role of inflammation in PML, and define prognostic markers of disease evolution.
详细描述
To determine precisely what are the host or viral factors that may predict a favorable outcome for PML patients and the role of inflammation in preventing JCV from causing brain disease. One of the goals of this study is to help establish non-invasive markers of PML evolution by studying the brain metabolism in PML lesions using Magnetic Resonance Imaging (MRI), Magnetic Spectroscopy (MRS) and other advanced imaging modalities.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •PML patients of 18 years of age or older will be included in this study.
排除标准
- •Presence of opportunistic brain lesions other than PML. ( e.g., toxoplasmosis, lymphoma)
- •Presence of confounding neurological disorder such as brain neoplasm etc.
- •In addition patients with a contraindication to MRI examination will be excluded from study. Contraindications to the MRI examination include:
- •Medically unstable or hematological, renal, or hepatic dysfunction.
- •Cardiac pacemaker
- •Internal clips,
- •Metal implants, or external clips with 10 mm of the head.
- •Metal in the eyes.
- •Claustrophobia
研究者
Chen Sabrina Tan
principal investigator
Beth Israel Deaconess Medical Center
研究点 (1)
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